Pyridinium-Based Brønsted Acidic Ionic Liquid as a Highly Efficient Catalyst for One-Pot Synthesis of Dihydropyrimidinones
Pyridinium-Based Brønsted Acidic Ionic Liquid as a Highly Efficient Catalyst for One-Pot Synthesis of Dihydropyrimidinones
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DOI：
10.1080/00397911.2010.523488
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发表时间：
2012-01
影响因子：
2.1
通讯作者：
A. Hajipour;M. Seddighi
中科院分区：
文献类型：
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作者：
A. Hajipour;M. Seddighi
摘要 本文报道了新型布朗斯台德酸性离子液体 3-羧基吡啶鎓硫酸氢盐 ([Hcpy]HSO4) 的合成和表征。这种可重复使用、廉价且绿色的催化剂用于1,3-二羰基化合物、芳香醛和脲或硫脲的一锅缩合，合成相应的3,4-二氢嘧啶-2(1H)-酮。反应在无溶剂和绿色条件下进行。该程序在非常短的反应时间内以优异的产率提供了产物。图解摘要
Abstract In this work, the synthesis and characterization of 3-carboxypyridinium hydrogensulfate ([Hcpy]HSO4) as a new Brønsted acidic ionic liquid are reported. This reusable, inexpensive, and green catalyst was employed for one-pot condensation of 1,3-dicarbonyl compounds, aromatic aldehydes and urea or thiourea for the synthesis of the corresponding 3,4-Dihydropyrimidin-2(1H)-ones. The reactions were carried out under solvent-free and green conditions. The procedure gave the products in excellent yields within very short reaction times. GRAPHICAL ABSTRACT