Childhood trauma and METH abuse among men who have sex with men: Implications for intervention.
Childhood trauma and METH abuse among men who have sex with men: Implications for intervention.
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DOI：
10.1016/j.jpsychires.2015.09.009
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发表时间：
2016-01
影响因子：
4.8
通讯作者：
Nemeroff CB
中科院分区：
文献类型：
--
作者：
Lopez-Patton M;Kumar M;Jones D;Fonseca M;Kumar AM;Nemeroff CB
甲基苯丙胺（METH）已成为南佛罗里达最广泛滥用的药物之一，特别是在可能是或可能不是艾滋病毒血清阳性的男男性行为者中。据报道，在感染艾滋病毒的男男性行为者中，儿童期创伤的发生率很高，但是，儿童期创伤和情绪障碍与艾滋病毒感染者使用甲基苯丙胺之间的关系尚未得到全面探讨。更好地了解这些因素之间的关联可以改善现有的药物滥用治疗干预策略和医疗方案（例如，药物依从性），以提高男性冰毒滥用者的积极健康结果，他们的心理后果是童年虐待。本研究，作为一个更大的研究的一部分，探讨了童年创伤和抑郁症的发生在一组HIV血清阳性METH滥用MSM。METH使用者的抑郁症状严重程度明显高于非METH使用者（p <0.001）。无论艾滋病毒感染状况如何，甲羟甲基安非他明使用者报告的儿童遭受情感、身体和性虐待的频率也高于非甲羟甲基安非他明使用者（p < .001）。在冰毒使用者中，抑郁症是由童年情感忽视预测的。这些结果表明，童年虐待可能与情绪困扰的发展有关（例如，抑郁症）和这一人群中甲基苯丙胺/药物滥用的流行率较高。这些发现对药物滥用干预措施具有重要意义，特别是针对MSM中的METH成瘾。处理儿童创伤和抑郁症可能在提高甲基苯丙胺成瘾干预措施的有效性方面发挥关键作用。
Methamphetamine (METH) has become one of the most widely abused drugs in South Florida, particularly among MSM who may or may not be HIV seropositive. High rates of childhood trauma have been reported among HIV-infected MSM, but, the association of childhood trauma, and mood disorders with methamphetamine use in HIV-infected men, has not been comprehensively explored. A better understanding of the association between these factors could improve existing substance abuse treatment intervention strategies and medical treatment programs (e.g., medication adherence) to enhance positive health outcomes for male meth abusers living with the psychological consequences of childhood abuse. This study, as part of a larger study, examined the occurrence of childhood trauma and depression in a group of HIV seropositive METH abusing MSM. Significantly higher levels of depression symptom severity were found among METH users relative to non-METH users (p < .001). Irrespective of HIV status, METH users also reported higher frequencies of emotional, physical and sexual child abuse relative to non-METH users (p < .001). Among meth users, depression was predicted by childhood emotional neglect. These results suggest that childhood maltreatment may be implicated in the development of emotional distress (e.g., depression) and higher prevalence of methamphetamine/drug abuse in this population. These findings have important implications for substance abuse interventions, specifically targeting METH addiction among MSM. Addressing childhood trauma and depression may play a key role in enhancing the effectiveness of interventions for methamphetamine addiction.