RELATION OF ADIPOSITY TO BLOOD PRESSURE AND DEVELOPMENT OF HYPERTENSION
RELATION OF ADIPOSITY TO BLOOD PRESSURE AND DEVELOPMENT OF HYPERTENSION
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DOI：
10.7326/0003-4819-67-1-48
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发表时间：
1967-01-01
影响因子：
39.2
通讯作者：
MCNAMARA, PM
中科院分区：
文献类型：
--
作者：
KANNEL, WB;BRAND, N;MCNAMARA, PM
自 1949 年以来，弗雷明汉研究对 5,127 名成年男性和女性进行了调查，调查了现有血压和随后发生的高血压与先前肥胖指标的关系，这些成年男性和女性每两年跟踪一次动脉粥样硬化和高血压血管疾病的发展情况。发现相对体重、观察到的体重变化和皮褶厚度与现有血压水平和随后的高血压发生率明显相关。无论评估如何，先前血压正常的个体患高血压的风险与超重程度成正比。通过检查在相对瘦的前臂和上臂中获得的肥胖与血压的关系，排除了在手臂肥胖的受试者中间接测定血压时出现重大伪影的可能性。在该人群的臂围范围内，无法证明臂围对血压的影响与相关的肥胖程度无关。随着体型的增加而观察到的血压升高是否直接归因于脂肪组织的积累，目前还没有答案。研究发现，瘦高血压患者患肥胖症的倾向增加，反之亦然，而已经肥胖的血压正常的受试者仅在一段时间滞后后才患上高血压，这表明两者之间的关系既不简单也不直接。似乎可以合理地得出这样的结论：肥胖会导致 30 岁以上的成年男性和女性患上高血压，并且对高血压的发展做出重大贡献。这并不是由于臂围较大而导致血压伪影的结果。
The relation of existing blood pressure and subsequent development of hypertension to antecedent measures of adiposity was investigated in 5,127 adult men and women being followed biennially for the development of atherosclerotic and hypertensive vascular disease in the Framingham Study since 1949. Relative body weight, weight change under observation, and skinfold thickness was found to be distinctly related to existing blood pressure level and to the subsequent rate of development of hypertension. The risk of hypertension in previously normotensive individuals was proportional to the degree of overweight however assessed. The possibility of a substantial artifact in indirect blood pressure determination in subjects with fat arms was excluded by an examination of the relation of adiposity to blood pressure as obtained in the relatively lean forearm as well as the upper arm. Within the range of arm girths in this population, no effect of arm girth on blood pressure independent of the associated degree of adiposity could be demonstrated. Whether or not the rise in blood pressure observed to occur with increase in body build is directly due to the accumulation of adipose tissue remains unanswered. The finding that lean hypertensives had an increased tendency to develop obesity as well as the converse, and that already obese normotensive subjects developed hypertension only after some time lag, suggests a relationship which is neither simple nor direct. It seems reasonable to conclude that adiposity predisposes and makes a significant contribution to development of hypertension in adult men and women beyond age 30. This is not the result of a blood pressure artifact due to a larger arm circumference.