Dynamic Blood Oxygen Level-dependent MR Imaging of Muscle: Comparison of Postocclusive Reactive Hyperemia in Young Smokers and Nonsmokers
Dynamic Blood Oxygen Level-dependent MR Imaging of Muscle: Comparison of Postocclusive Reactive Hyperemia in Young Smokers and Nonsmokers
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DOI：
10.2463/mrms.2014-0105
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发表时间：
2015-01-01
影响因子：
3
通讯作者：
Sugimura, Kazuro
中科院分区：
文献类型：
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作者：
Nismii, Tatsuya;Kono, Atsushi K.;Sugimura, Kazuro
目的：动态肌肉血氧水平依赖（BOLD）磁共振（MR）成像对早期肌肉血流反应（MFR）功能评估的作用尚不清楚。我们根据年轻吸烟者和非吸烟者在闭合性反应性充血期间动态肌肉BOLD MR成像得出的MFR研究了吸烟对血管功能的影响。方法：16名健康男性志愿者（8名吸烟者，8名非吸烟者，平均年龄30.4±4.6岁）接受左小腿肌肉的BOLD MR成像。在袖带压缩技术引起的反应性充血期间，我们使用3特斯拉单次多回波梯度回波平面成像序列测量肌肉BOLD （mB）。我们研究的反应性充血期的两个关键mB变量是充血峰值的一半（T-1/2peak）和峰值（TTP），每个变量都是从袖带充血开始测量的。我们使用韦尔奇检验来评估吸烟者和非吸烟者在这些方面的差异。结果：反应性充血组吸烟者t -1/2峰和TTP明显延长（P < 0.05）。吸烟者t -1/2峰值为13.8 +/- 5.4s，非吸烟者为7.6 +/- 1.5 s；吸烟者TTP峰值为67.5 +/- 18.8 s，非吸烟者为45.4 +/- 7.1 s。结论：封闭后反应性充血期间小腿肌肉动态BOLD MR成像显示，年轻吸烟者和非吸烟者之间t -1/2峰和TTP有统计学差异，表明MFR存在早期吸烟相关恶化。
Purpose: The role of early stage functional assessment of muscle blood flow response (MFR) by dynamic muscle blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is unknown. We investigated the effect of smoking on vascular function according to MFR derived from dynamic muscle BOLD MR imaging during postocclusive reactive hyperemia in young smokers and nonsmokers.Methods: Sixteen healthy male volunteers (8 smokers, 8 nonsmokers; mean age, 30.4 +/- 4.6 years) underwent BOLD MR imaging of the left calf muscle. During reactive hyperemia provoked by a cuff-compression technique, we measured muscle BOLD (mB) using a 3-tesla single-shot multi-echo gradient-echo echo-planar imaging sequence. The 2 key mB variables in the reactive hyperemic phase that we studied were times to half hyperemic peak (T-1/2peak) and peak (TTP), each measured from cuff deflation. We used the Welch test to assess differences in these between smokers and nonsmokers.Results: T-1/2peak and TTP were significantly longer in smokers (P < 0.05) in reactive hyperemia. T-1/2peak was 13.8 +/- 5.4s in smokers and 7.6 +/- 1.5 s in nonsmokers, and TTP was 67.5 +/- 18.8 s in smokers and 45.4 +/- 7.1 s in nonsmokers.Conclusion: Dynamic BOLD MR imaging of calf muscle during postocclusive reactive hyperemia demonstrated statistically significant differences in T-1/2peak and TTP between young smokers and nonsmokers, indicating the presence of early stage smoking-related deterioration in MFR.