Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents
Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents
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DOI：
10.1039/b616085a
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Meunier, Bernard
中科院分区：
文献类型：
--
作者：
Deraeve, Celine;Pitie, Marguerite;Meunier, Bernard
与clioquinol（一种体内活性的8-羟基喹啉衍生物）相比，基于含有两个相连的8-羟基喹啉的四齿配体的策略可以显著提高在Cu(II), Zn（II）和Fe（III）存在时防止β -淀粉样肽沉淀的能力。
A strategy based on the use of a tetradentate ligand containing two linked 8-hydroxyquinolines allowed a significant increase in the ability to protect against beta-amyloid peptide precipitation in the presence of Cu(II), Zn(II) and Fe(III) when compared to clioquinol, a 8-hydroxyquinoline derivative active in vivo.