Isometric torque about the knee joint generated by microstimulation of the cat L6 spinal cord.
Isometric torque about the knee joint generated by microstimulation of the cat L6 spinal cord.
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DOI：
10.1109/86.750551
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发表时间：
1999-03-01
期刊：
影响因子：
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通讯作者：
Roppolo, J R
中科院分区：
文献类型：
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作者：
Tai, C;Booth, A M;Roppolo, J R
通过使用单个微电极微刺激猫L6脊髓，在膝关节周围产生等距扭矩。扭矩响应随微刺激位置而变化。在L6脊髓腹外侧位置的微刺激产生了可观的伸展扭矩。刺激参数（强度、频率和脉冲宽度）也会影响伸展扭矩。特定的刺激参数（100微安强度，40 Hz频率和0.20 ms脉冲宽度）似乎最适合于映射基于膝关节扭矩响应的脊髓。低水平的共同收缩的伸肌和屈肌时，可以实现伸展扭矩产生，但也随刺激位置。在L6腹侧角的某些位置，微刺激可以引起持续伸展至少4分钟，扭矩只有轻微的变化。这项研究表明，有可能恢复下肢功能的患者脊髓损伤以上的腰椎水平。
Isometric torque was generated about the knee joint by microstimulation of the cat L6 spinal cord using a single microelectrode. The torque responses varied with microstimulation location. Appreciable extension torque was generated by microstimulation in ventrolateral locations of the L6 spinal cord. Stimulation parameters (intensity, frequency and pulse-width) also influenced the extension torque. Specific stimulation parameters (100 microA intensity, 40 Hz frequency and 0.20 ms pulse-width) appear best suited for mapping the spinal cord based on knee joint torque responses. Low levels of cocontraction of the extensor and flexor could be achieved when extension torque was produced, but also varied with the stimulation locations. There are locations in the L6 ventral horn where microstimulation could evoke sustained extension for at least 4 min with only a slight change in torque. This study suggests the possibility of restoring lower limb function in patients with spinal cord injury above the lumbar level.