Update on the Burkholderia cepacia complex
Update on the Burkholderia cepacia complex
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DOI：
10.1097/01.mcp.0000181475.85187.ed
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发表时间：
2005-11-01
影响因子：
3.3
通讯作者：
LiPuma, JJ
中科院分区：
文献类型：
--
作者：
LiPuma, JJ
综述目的洋葱伯克霍尔德氏菌复合体由一组相关细菌组成，能够在囊性纤维症患者中引起危及生命的呼吸道感染。本文综述了洋葱伯克霍尔德菌复合体感染在囊性纤维化中的研究进展，重点介绍了洋葱伯克霍尔德氏菌复合体感染的分类、临床微生物学和流行病学，以及与洋葱伯克霍尔德氏菌复合体感染相关的自然病史和临床转归。这些名称是首选的命名法，取代了以前的‘genomovar’名称。来自几个国家的研究重申，囊性纤维化中洋葱伯克霍尔德氏菌复合体感染的主要原因是两种伯克霍尔德氏菌，即盲肠伯克霍尔德氏菌和多食伯克霍尔德氏菌。细菌基因分型研究表明，特定的洋葱伯克霍尔德氏菌复合菌株可感染多发性囊性纤维化患者，这意味着它们可能具有增强的患者间传播能力。新出现的临床结果数据表明，至少这些所谓的可传播或流行菌株中的一些在囊性纤维化宿主中也更具毒力。正在进行的研究旨在更好地了解洋葱伯克霍尔德氏菌复合体生态，确定洋葱伯克霍尔德氏菌复合体毒力因子和致病机制，并确定不同菌株的相对毒力。摘要我们对洋葱伯克霍尔德氏菌复合体的了解取得的重大进展为进一步努力奠定了关键基础，最终将使更好的感染控制和新疗法的开发用于治疗囊性纤维化患者的洋葱伯克霍尔德氏菌复合体感染。
Purpose of review The Burkholderia cepacia complex is comprised of a group of related bacterial species that are capable of causing life-threatening respiratory tract infection in persons with cystic fibrosis. This article reviews advances in our understanding of Burkholderia cepacia complex infection in cystic fibrosis, focusing on the taxonomy, clinical microbiology, and epidemiology, as well as the natural history and clinical outcomes associated with Burkholderia cepacia complex infection.Recent findings Each of the nine species of the Burkholderia cepacia complex has now received a formal species name. These names are the preferred nomenclature, replacing the former 'genomovar' designations. Studies from several countries reiterate that two species, Burkholderia cenocepacia and Burkholderia multivorans, account for most Burkholderia cepacia complex infection in cystic fibrosis. Bacterial genotyping studies indicate that specific Burkholderia cepacia complex strains infect multiple cystic fibrosis patients, implying that they may have an enhanced capacity for interpatient spread. Emerging clinical outcomes data suggest that at least some of these so-called transmissible or epidemic strains are also more virulent in the cystic fibrosis host. Ongoing research is aimed at gaining a better understanding of Burkholderia cepacia complex ecology, defining Burkholderia cepacia complex virulence factors and pathogenic mechanisms, and determining the relative virulence of distinct strains.Summary Significant advances in our understanding of the Burkholderia cepacia complex serve as a critical foundation for further efforts that ultimately will enable better infection control and the development of novel therapeutics to treat Burkholderia cepacia complex infection in persons with cystic fibrosis.