Hypothalamic abnormalities in schizophrenia: Sex effects and genetic vulnerability
Hypothalamic abnormalities in schizophrenia: Sex effects and genetic vulnerability
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DOI：
10.1016/j.biopsych.2006.06.027
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发表时间：
2007-04-15
影响因子：
10.6
通讯作者：
Tsuang, Ming T.
中科院分区：
文献类型：
--
作者：
Goldstein, Jill M.;Seidman, Larry J.;Tsuang, Ming T.
背景：这是一个独特的下丘脑磁共振成像（MRI）研究精神分裂症，一个重要的区域在边缘系统。我们假设异常体积增加，与单一家庭（一个患病成员）相比，多重家庭（多于一个患病成员）的严重程度更大。我们检验了正常的下丘脑两性二态性在精神分裂症中被破坏的假设。方法：对88例DSM-III-R精神分裂症患者（单纯性40例，多重性48例）、43例一级非精神病性亲属和48例正常对照者进行系统比较。使用1.5特斯拉通用电气扫描仪获得结构MRI扫描，并使用连续的3.1 mm切片分割下丘脑前后。使用相关数据的一般线性模型和广义估计方程来比较左右下丘脑的病例、亲属和对照，控制年龄、性别和总脑容量。斯皮尔曼的下丘脑体积与焦虑的相关性被计算出来，开始检查与结构异常相关的觉醒。结果：研究结果显示，在患者和非精神病亲属中，下丘脑体积显著增加，特别是在室旁核和乳状体核区域。从单一病例到多重病例，这种增加是线性的，与焦虑正相关，并且在女性中有更大的倾向。结论：研究结果对理解精神分裂症的遗传易感性和内分泌异常的高发率具有重要意义。
Background: This is a unique hypothalamic magnetic resonance imaging (MRI) study in schizophrenia, an important region in the limbic system. We hypothesized abnormal volumetric increases, with greater severity in multiplex families (more than one ill member) compared with simplex families (one ill). We tested the hypothesis that normal hypothalamic sexual dimorphism is disrupted in schizophrenia.Methods: Eighty-eight DSM-III-R schizophrenia cases (40 simplex and 48 multiplex), 43 first-degree nonpsychotic relatives, and 48 normal comparisons systematically were compared. A 1.5-Tesla General Electric scanner was used to acquire structural MRI scans, and contiguous 3.1-mm slices were used to segment anterior and posterior hypothalamus. General linear model for correlated data and generalized estimating equations were used to compare cases, relatives, and controls on right and left hypothalamus, controlled for age, sex, and total cerebral volume. Spearman's correlations of hypothalamic volumes with anxiety were calculated to begin to examine arousal correlates with structural abnormalities.Results: Findings demonstrated significantly increased hypothalamic volume in cases and nonpsychotic relatives, particularly in regions of paraventricular and mammillary body nuclei, respectively. This increase was linear from simplex to multiplex cases, was positively correlated with anxiety, and had a greater propensity in women.Conclusions: Findings suggest important implications for understanding genetic vulnerability of schizophrenia and the high rate of endocrine abnormalities.