Area Under the Real-Time Contact Force Curve (Force-Time Integral) Predicts Radiofrequency Lesion Size in an In Vitro Contractile Model
Area Under the Real-Time Contact Force Curve (Force-Time Integral) Predicts Radiofrequency Lesion Size in an In Vitro Contractile Model
复制标题
DOI：
10.1111/j.1540-8167.2010.01750.x
复制
发表时间：
2010-09-01
影响因子：
2.7
通讯作者：
Leo, Giovanni
中科院分区：
文献类型：
--
作者：
Shah, Dipen C.;Lambert, Hendrik;Leo, Giovanni
方法和结果：将一个开放尖端的冲洗导管连接到一个可移动的支架上，该支架包含一个动态力传感器，允许闭环控制，以实现导管尖端和放置在地板上的牛骨骼肌之间所需的力变化。在(1)20 g恒定接触(C)、(2)20 g峰值和10 g最低点的可变接触(V)和(3)20 g峰值和0 g最低点的间歇接触(I)失去接触时，提供20和40 W 60秒的射频能量（17 cc/min灌溉）。V和I方案分别在导管移动次数为50和100次/min和2个收缩期：舒张期时间比（50:50和30:70）下进行。CF曲线下的面积作为FTI计算。测量的FTI在C时最高，在V时居中，在I时最低，并与病变体积呈线性相关（P < 0.0001，在20和40 W）。病变体积C组最大，V组居中，I组最小（C vs V、V vs I、C vs I差异均P < 0.05）。结论：病灶大小与测量的接触FTI呈线性相关。恒定的接触产生最大的和间歇的接触，最小的损伤，尽管恒定的射频功率和相同的峰值接触力。（journal of cardiovascular Electrophysiol, Vol. 21, pp. 1038-1043, 2010年9月）。
Methods and Results: An open-tip irrigated catheter was attached to a movable mount incorporating a dynamic force sensor allowing closed loop control to achieve desired force variations between the catheter tip and bovine skeletal muscle placed on a ground plate. RF energy (20 and 40 W for 60 seconds, 17 cc/min irrigation) was delivered during (1) constant contact (C) at 20 g, (2) variable contact (V) with a 20 g peak and 10 g nadir, and (3) intermittent contact (I) with a 20 g peak and 0 g nadir with loss of contact. V and I protocols were performed at 50 and 100 catheter movements/min and 2 systole:diastole time ratios (50:50 and 30:70). The area under the CF curve was calculated as the FTI. Measured FTI was highest in C, intermediate during V and lowest during I and correlated linearly with lesion volume (P < 0.0001 for 20 and 40 W). Lesion volume was highest in group C, intermediate in V and lowest in group I (P < 0.05 for C vs V, V vs I, and C vs I).Conclusions: Lesion size correlates linearly with measured contact FTI. Constant contact produces the largest and intermittent contact the smallest lesions despite constant RF power and identical peak contact forces. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1038-1043, September 2010).