Conserved Spatzle/Toll signaling in dorsoventral patterning of Xenopus embryos
Conserved Spatzle/Toll signaling in dorsoventral patterning of Xenopus embryos
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DOI：
10.1016/s0925-4773(98)00003-3
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发表时间：
1998-02-01
影响因子：
2.6
通讯作者：
Rupp, RAW
中科院分区：
文献类型：
--
作者：
Armstrong, NJ;Steinbeisser, H;Rupp, RAW
Spatzle/Toll信号通路通过产生一种梯度的核背部蛋白来控制果蝇腹轴的形成。DRADAL控制着下游的调控因子DPP和SOG，它们的模式功能在昆虫和脊椎动物之间是保守的。虽然没有实验证据表明上游事件也是保守的，但我们开始研究脊椎动物胚胎是否可以对苍蝇背部路径的母体成分做出反应。在这里，我们展示了异源Easter，Spatzle和Toll蛋白在UV腹腔化的非洲爪哇胚胎中的背部活性，这被共同注射的显性仙人掌变体所抑制。我们的结论是，背侧信号通路是双侧大脑中保守的背腹(d/v)模式系统的组成部分。(C)1998年爱思唯尔爱尔兰科学有限公司。
The Spatzle/Toll signaling pathway controls ventral axis formation in Drosophila by generating a gradient of nuclear Dorsal protein. Dorsal controls the downstream regulators dpp and sog, whose patterning functions are conserved between insects and vertebrates. Although there is no experimental evidence that the upstream events are conserved as well, we set out to ask if a vertebrate embryo can respond to maternal components of the fly Dorsal pathway. Here we demonstrate a dorsalizing activity for the heterologous Easter, Spatzle and Toll proteins in UV-ventralized Xenopus embryos, which is inhibited by a co-injected dominant Cactus variant. We conclude that the Dorsal signaling pathway is a component of the conserved dorsoventral (d/v) patterning system in bilateria. (C) 1998 Elsevier Science Ireland Ltd.