Potential of vitamin E as an antioxidant adjunct in Wilson's disease
Potential of vitamin E as an antioxidant adjunct in Wilson's disease
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DOI：
10.1016/j.mehy.2009.05.025
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发表时间：
2009-12-01
影响因子：
4.7
通讯作者：
Fryer, Michael J.
中科院分区：
文献类型：
--
作者：
Fryer, Michael J.
威尔逊病是一种罕见的铜代谢遗传性疾病，导致线粒体铜超载和器官损伤，特别是肝脏。氧化应激是中央的发病机制和情况下，简要地作出了严格的试验维生素E作为抗氧化剂的辅助剂的基础上，早期的推论研究，其水平在血液和肝脏的威尔逊氏病患者和其影响的动物模型的疾病。(C)2009爱思唯尔有限公司保留所有权利。
Wilson's disease is a rare genetic illness of copper metabolism, which leads to copper-overload in mitochondria and organ damage, especially to the liver. Oxidative stress is central to the pathogenesis and a case is briefly made for rigorous trials of vitamin E as an antioxidant adjunct based on earlier corollary studies of its levels in the blood and liver of Wilson's disease patients and its effects in animal models of the illness. (C) 2009 Elsevier Ltd. All rights reserved.