Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells.
Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells.
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DOI：
10.4049/jimmunol.1402004
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发表时间：
2015-05-01
期刊：
影响因子：
--
通讯作者：
Klinman DM
中科院分区：
文献类型：
--
作者：
Wang J;Shirota Y;Bayik D;Shirota H;Tross D;Gulley JL;Wood LV;Berzofsky JA;Klinman DM
肿瘤通过占据抑制肿瘤杀伤T细胞和NK细胞活性的免疫抑制微环境而持续存在。单核细胞髓系来源的抑制细胞(MMDSC)是这种免疫抑制环境的重要组成部分。我们发现，从癌症患者分离的mMDSC的抑制活性可以被TLR7/8激动剂逆转，TLR7/8激动剂可以诱导人mMDSC分化为具有肿瘤杀伤活性的M1样巨噬细胞。相反，靶向TLR1/2的激动剂使mMDSC成熟为免疫抑制的M2样巨噬细胞。这两类巨噬细胞在表型和功能上是不同的，在基因表达谱上也不同。TLR7/8激动剂逆转mMDSC介导的免疫抑制的能力表明它们可能是肿瘤免疫治疗的有用辅助药物。
Tumors persist by occupying immunosuppressive microenvironments that inhibit the activity of tumoricidal T and NK cells. Monocytic myeloid-derived suppressor cells (mMDSC) are an important component of this immunosuppressive milieu. We find that the suppressive activity of mMDSC isolated from cancer patients can be reversed by treatment with TLR 7/8 agonists which induce human mMDSC to differentiate into tumoricidal M1-like macrophages. In contrast, agonists targeting TLR 1/2 cause mMDSC to mature into immunosuppressive M2-like macrophages. These two populations of macrophage are phenotypically and functionally discrete and differ in gene expression profile. The ability of TLR 7/8 agonists to reverse mMDSC mediated immune suppression suggests that they might be useful adjuncts for tumor immunotherapy.
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影响因子：
5.5
作者：
Du, Jun;Wu, Zhiyuan;Ren, Shurong;Wei, Yong;Gao, Meihua;Randolph, Gwendalyn J.;Qu, Chunfeng
通讯作者：
Qu, Chunfeng
DOI：
10.1073/pnas.0631696100
发表时间：
2003-05-27
影响因子：
11.1
作者：
Lee, J;Chuang, TH;Cottam, HB
通讯作者：
Cottam, HB
影响因子：
8.4
作者：
Balsari, A;Tortoreto, M;Pratesi, G
通讯作者：
Pratesi, G
影响因子：
11.2
作者：
Mao, Yumeng;Poschke, Isabel;Kiessling, Rolf
通讯作者：
Kiessling, Rolf
影响因子：
5.5
作者：
Klaschik, Sven;Tross, Debra;Klinman, Dennis M.
通讯作者：
Klinman, Dennis M.