Can histological assessment predict the outcome in interstitial cystitis?
Can histological assessment predict the outcome in interstitial cystitis?
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组织学评估可以预测间质性膀胱炎的结果吗？
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Anthony R. Stone
中科院分区：
文献类型：
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作者：
J. MacDermott;G. Charpied;Henry Tesluk;Anthony R. Stone
在一项回顾性研究中，我们将 39 名间质性膀胱炎患者的结果与初次诊断性膀胱活检的组织学结果进行了比较。每次活检均评估炎症和纤维化的程度以及肥大细胞计数。评估年龄、症状持续时间、频率、夜尿、疼痛和膀胱容量等临床特征的预后相关性。该研究显示诊断时组织学结果的严重程度与疾病的最终结果之间没有统计相关性。超过 50% 的严重组织学异常患者对保守治疗有反应。尽管大多数轻度病理改变的患者对保守治疗有反应，但有些患者确实需要手术干预。两组患者的疼痛、夜尿和膀胱容量的临床特征存在显着差异。然而，前两个特征受许多变量的影响，而后者的范围可能太宽，无法用作预后指标。只有患者对保守治疗的反应才能表明哪些人没有得到帮助以及哪些人最终可能需要手术治疗。
In a retrospective study we compared the outcome of 39 patients with interstitial cystitis to the histological findings at initial diagnostic bladder biopsy. The degree of inflammation and fibrosis and the mast cell counts were assessed on each biopsy. The prognostic relevance of the clinical features of age, duration of symptoms, frequency, nocturia, pain and bladder capacity was assessed. The study showed no statistical correlation between the severity of histological findings at diagnosis and the eventual outcome of the disease. Over 50% of patients with severe histological abnormalities responded to conservative treatment. Although the majority of patients with mild pathological changes responded to conservative treatment, some did require surgical intervention. The clinical features of pain, nocturia and bladder capacity showed significant differences between the 2 patient groups. However, the former 2 features are subject to many variables and the latter probably has too wide a range to be useful as a prognostic indicator. Only the response of patients to conservative treatment will indicate those who are not being helped and who may eventually require surgical treatment.