STATISTICAL PROPERTIES OF SEGREGATING SITES
STATISTICAL PROPERTIES OF SEGREGATING SITES
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DOI：
10.1006/tpbi.1995.1025
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发表时间：
1995-10-01
影响因子：
1.4
通讯作者：
FU, YX
中科院分区：
文献类型：
--
作者：
FU, YX
导致样品的分离位点的突变可以通过样品中继承突变核苷酸的序列的数量来分类;它也可以通过在所得分离侧的两个分离核苷酸的频率来分类。我们将突变的大小定义为样品中继承突变核苷酸的序列的数量，并且将突变的类型（分离位点）定义为分离核苷酸的频率的最小值。这两类突变中的每一类都类似于基因样本中的等位基因类型。在中性Wright-Fisher模型下，本文导出了每种大小和类型的突变频率的均值和方差，以及两种不同大小和两种不同类型的突变数之间的协方差。这些结果的潜在应用进行了讨论。(C)出版社：Academic Press
A mutation leading to a segregating site of a sample can be classified by the number of sequences in the sample that inherits the mutant nucleotide; it can also be classified by the frequencies of the two segregating nucleotides at the resulting segregating side. We define the size of a mutation to be the number of sequences in the sample that inherits the mutant nucleotide and the type of mutation (segregating site) to be the smallest value of the frequencies of segregating nucleotides. Each of these two classifications of mutations is analogous to allelic types in a sample of genes. Assuming the neutral Wright-Fisher model, we derived in this paper the mean and variance of the frequency of mutations of each size and type, and the covariance between the numbers of mutations of two different sizes and two different types. Potential applications of these results are discussed. (C) 1995 Academic Press, Inc.