Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration
复制标题
DOI：
10.1136/jnnp-2020-323487
复制
发表时间：
2020-09-01
影响因子：
11
通讯作者：
Borroni, Barbara
中科院分区：
文献类型：
--
作者：
Benussi, Alberto;Karikari, Thomas K.;Borroni, Barbara
目的：为了评估血清神经丝蛋白光（NfL）和血清磷酸化Tau（181）（p-Tau（181））在额颞叶变性（FTLD）患者中的诊断和预后价值，方法：在这项回顾性研究中，对417名参与者进行了研究，我们用超灵敏单分子阵列（Simoa）方法分析了血清NfL和p-Tau（181）浓度。我们评估了血清生物标志物在FTLD、阿尔茨海默病（AD）和健康老龄化之间的鉴别诊断中的诊断价值;它们作为疾病严重程度标志物的作用，评估与临床变量、横断面脑成像和神经生理学数据的相关性;它们作为预后标志物的作用，考虑到它们预测FTLD生存概率的能力。我们观察到FTLD综合征患者的血清NfL水平显著高于健康对照组，而p-Tau水平低于AD患者（181）。血清NfL浓度在区分FTLD和健康对照方面显示出高准确性（曲线下面积（AUC）：0.86，p
Objective: To assess the diagnostic and prognostic value of serum neurofilament light (NfL) and serum phospho-Tau(181)(p-Tau(181)) in a large cohort of patients with frontotemporal lobar degeneration (FTLD).Methods: In this retrospective study, performed on 417 participants, we analysed serum NfL and p-Tau(181)concentrations with an ultrasensitive single molecule array (Simoa) approach. We assessed the diagnostic values of serum biomarkers in the differential diagnosis between FTLD, Alzheimer's disease (AD) and healthy ageing; their role as markers of disease severity assessing the correlation with clinical variables, cross-sectional brain imaging and neurophysiological data; their role as prognostic markers, considering their ability to predict survival probability in FTLD.Results: We observed significantly higher levels of serum NfL in patients with FTLD syndromes, compared with healthy controls, and lower levels of p-Tau(181)compared with patients with AD. Serum NfL concentrations showed a high accuracy in discriminating between FTLD and healthy controls (area under the curve (AUC): 0.86, p