Regulation of protein stability by GSK3 mediated phosphorylation.
Regulation of protein stability by GSK3 mediated phosphorylation.
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DOI：
10.4161/cc.8.24.10111
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发表时间：
2009-12-15
期刊：
影响因子：
--
通讯作者：
Gumbiner BM
中科院分区：
文献类型：
--
作者：
Xu C;Kim NG;Gumbiner BM
糖原合成酶-3(GSK3)在多种信号通路中发挥重要作用，调节细胞增殖、分化、凋亡和胚胎发育等多种细胞过程。在典型的Wnt信号通路中，Gsk3的磷酸化通过破坏复合体介导蛋白酶体靶向和β-连环蛋白的降解。我们最近报道了一项生化筛查，发现了多个额外的蛋白质底物，它们的稳定性受到Wnt信号和/或GSK3的调节，这些对于Wnt/GSK3对不同细胞过程的调节具有重要意义。在这篇文章中，我们还提出了一种基于生物信息学的蛋白质筛选，其稳定性可能由GSK3和β-TrCP控制，SCF E3泛素连接酶负责Wnt信号通路中β-连环蛋白的降解。此外，我们还回顾了文献中所描述的各种GSK3调节的蛋白分解底物。我们认为GSK3磷酸化依赖的蛋白分解是细胞用来调节各种细胞过程以响应信号的一种广泛的机制。
Glycogen synthase kinase-3 (GSK3) plays important roles in numerous signaling pathways that regulate a variety of cellular processes including cell proliferation, differentiation, apoptosis and embryonic development. In the canonical Wnt signaling pathway, GSK3 phosphorylation mediates proteasomal targeting and degradation of β-catenin via the destruction complex. We recently reported a biochemical screen that discovered multiple additional protein substrates whose stability is regulated by Wnt signaling and/or GSK3 and these have important implications for Wnt/GSK3 regulation of different cellular processes. In this article, we also present a bio-informatics based screen for proteins whose stability may be controlled by GSK3 and β-Trcp, the SCF E3 ubiquitin ligase that is responsible for β-catenin degradation in the Wnt signaling pathway. Furthermore, we review various GSK3 regulated proteolysis substrates described in the literature. We propose that GSK3 phosphorylation dependent proteolysis is a widespread mechanism that the cell employs to regulate a variety of cell processes in response to signals.
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影响因子：
5.3
作者：
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通讯作者：
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5.3
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11.4
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8
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影响因子：
4.8
作者：
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通讯作者：
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