Molecular predictors of resistance training outcomes in young untrained female adults.
Molecular predictors of resistance training outcomes in young untrained female adults.
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未经训练的年轻女性阻力训练结果的分子预测因素。
DOI：
10.1152/japplphysiol.00605.2022
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Roberts,Micha
中科院分区：
文献类型：
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作者：
Smith,MorganA;Sexton,CaseyL;Smith,KristenA;Osburn,ShelbyC;Godwin,JoshuaS;Beausejour,JonathanP;Ruple,BradleyA;Goodlett,MichaelD;Edison,JosephL;Fruge,AndrewD;Robinson,AustinT;Gladden,LBruce;Young,KaelinC;Roberts,Micha
我们试图确定肌原纤维蛋白合成（MyoPS）对原始抗阻训练（RE）的反应，或卫星细胞数量和肌肉核糖体含量的慢性变化，是否与女性的肥大结果相关，或者在那些对抗阻训练（RT）反应较高（HR）或较低（LR）的人中存在差异。34名未经培训的大学年龄女性（23.4 ± 3.4 kg/m2）完成了10周RT方案（每周两次）。干预前后进行了身体成分和腿部成像评估、右腿股外侧肌活检和力量测试。使用复合评分（包括全身瘦/软组织质量（LSTM）、股外侧肌（VL）肌肉横截面积（mCSA）、大腿中部mCSA和硬拉强度的变化）描绘HR（n= 8）和LR（n= 8）的上下四分位数。在所有参与者中，训练显著（P< 0.05）增加了LSTM，VL mCSA，大腿中部mCSA，硬拉强度，平均肌纤维横截面积，卫星细胞丰度和肌纤维数量。HR组LSTM（P< 0.001）、VL mCSA（P< 0.001）、大腿中部mCSA（P< 0.001）和硬拉强度（P= 0.001）的增加大于LR组。HR和LR之间的首次24小时MyoPS反应相似（P= 0.367）。虽然肌肉总RNA浓度不存在显著的应答者×时间相互作用（即，核糖体含量增加（P= 0.888），卫星细胞丰度在HR中增加（P= 0.026），但在LR中没有增加（P= 0.628）。HR与LR相比，训练前LSTM（P= 0.010）、VL mCSA（P= 0.028）和大腿中部mCSA（P< 0.001）也更大。女性参与者增强卫星细胞反应RT，RT前更多的肌肉质量，表现出良好的阻力训练adaptations.NEW &值得注意的是，这项研究继续描绘肌肉生物学差异之间的低和高反应阻力训练，是独特的，女性人口进行了询问。正如先前的研究所报道的那样，卫星细胞数量的增加与阻力训练的积极反应有关。卫星细胞反应性，而不是每毫克组织中肌肉核糖体含量的变化，可能是描述女性阻力训练反应的更重要因素。
We sought to determine if the myofibrillar protein synthetic (MyoPS) response to a naïve resistance exercise (RE) bout, or chronic changes in satellite cell number and muscle ribosome content, were associated with hypertrophic outcomes in females or differed in those who classified as higher (HR) or lower (LR) responders to resistance training (RT). Thirty-four untrained college-aged females (23.4 ± 3.4 kg/m2) completed a 10-wk RT protocol (twice weekly). Body composition and leg imaging assessments, a right leg vastus lateralis biopsy, and strength testing occurred before and following the intervention. A composite score, which included changes in whole body lean/soft tissue mass (LSTM), vastus lateralis (VL) muscle cross-sectional area (mCSA), midthigh mCSA, and deadlift strength, was used to delineate upper and lower HR (n= 8) and LR (n= 8) quartiles. In all participants, training significantly (P< 0.05) increased LSTM, VL mCSA, midthigh mCSA, deadlift strength, mean muscle fiber cross-sectional area, satellite cell abundance, and myonuclear number. Increases in LSTM (P< 0.001), VL mCSA (P< 0.001), midthigh mCSA (P< 0.001), and deadlift strength (P= 0.001) were greater in HR vs. LR. The first-bout 24-hour MyoPS response was similar between HR and LR (P= 0.367). While no significant responder × time interaction existed for muscle total RNA concentrations (i.e., ribosome content) (P= 0.888), satellite cell abundance increased in HR (P= 0.026) but not LR (P= 0.628). Pretraining LSTM (P= 0.010), VL mCSA (P= 0.028), and midthigh mCSA (P< 0.001) were also greater in HR vs. LR. Female participants with an enhanced satellite cell response to RT, and more muscle mass before RT, exhibited favorable resistance training adaptations.NEW & NOTEWORTHYThis study continues to delineate muscle biology differences between lower and higher responders to resistance training and is unique in that a female population was interrogated. As has been reported in prior studies, increases in satellite cell numbers are related to positive responses to resistance training. Satellite cell responsivity, rather than changes in muscle ribosome content per milligrams of tissue, may be a more important factor in delineating resistance-training responses in women.