The two-century journey of Parkinson disease research
The two-century journey of Parkinson disease research
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DOI：
10.1038/nrn.2017.25
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发表时间：
2017-04-01
影响因子：
34.7
通讯作者：
Przedborski, Serge
中科院分区：
文献类型：
--
作者：
Przedborski, Serge
自两个世纪前首次正式描述帕金森病以来，我们对这种常见的神经退行性疾病的认识已经扩展到所有描述水平，从其临床表型的描绘到其神经病理特征、神经化学过程和遗传因素的识别。在此过程中，发现导致了关于疾病如何发展和进展的新假说，挑战了我们对神经退行性疾病如何对人类健康造成严重破坏的理解。在这篇时间线文章中，我重述了PD研究200年的迷人历程。
Since the first formal description of Parkinson disease (PD) two centuries ago, our understanding of this common neurodegenerative disorder has expanded at all levels of description, from the delineation of its clinical phenotype to the identification of its neuropathological features, neurochemical processes and genetic factors. Along the way, findings have led to novel hypotheses about how the disease develops and progresses, challenging our understanding of how neurodegenerative disorders wreak havoc on human health. In this Timeline article, I recount the fascinating 200-year journey of PD research.