REGIONAL CEREBRAL BLOOD-FLOW DURING BICUCULLINE-INDUCED SEIZURES IN THE NEWBORN PIGLET - EFFECT OF PHENOBARBITAL
REGIONAL CEREBRAL BLOOD-FLOW DURING BICUCULLINE-INDUCED SEIZURES IN THE NEWBORN PIGLET - EFFECT OF PHENOBARBITAL
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DOI：
10.1159/000457036
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
VERT, P
中科院分区：
文献类型：
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作者：
CLOZEL, M;DAVAL, JL;VERT, P
采用放射性微球技术研究了12头新生儿尿素麻醉仔猪、6头苯巴比妥（10 mg/kg）预处理仔猪和6头未使用苯巴比妥的仔猪在苯巴比妥诱发癫痫发作期间和发作后脑血流的变化。测定大鼠平均动脉血压（MABP）、PaO2 [O2张力]PaCO2和脑组织pH （CtpH）。癫痫发作时脑血流增加，基底节区（对照组和苯巴比妥组分别为98%和106%）比脑干、小脑和皮质区多。癫痫发作15分钟后，脑血流恢复到癫痫发作前值。在任何时候，对照组和苯巴比妥组之间没有显著差异。CBF增加与MABP增加相关（r = 0.753, P < 0.01），提示脑自动调节功能丧失。发作前后CBF与PaCO2有显著相关性，发作期间无显著相关性。CBF的增加与CtpH的早期升高显著相关（r = 0.570, P < 0.05），提示脑酸中毒与癫痫发作期间CBF增加的发病机制无关。
The changes in cerebral blood flow (CBF) during and after bicuculline-induced seizures were studied by the radioactive microsphere technique in 12 newborn, urethane-anesthetized piglets, 6 piglets pretreated with phenobarbital (10 mg/kg) and 6 without phenobarbital. The mean arterial blood pressure (MABP), PaO2 [O2 tension] PaCO2 and the cerebral tissue pH (CtpH) were measured. CBF was increased during seizure, more in basal ganglia (98 and 106% in the control and phenobarbital group, respectively) than in brainstem, cerebellum and cortex. Fifteen min after seizure, CBF has returned to preseizure values. There was no significant difference at any time between the control and phenobarbital group. The increase in CBF was correlated with an increase in MABP (r = 0.753, P < 0.01), suggesting a loss of cerebral autoregulation. CBF was significantly correlated with PaCO2 before and after seizure, but not during seizure. The increase in CBF was significantly correlated with an early increase in CtpH (r = 0.570, P < 0.05), suggesting that brain acidosis is not involved in the pathogenesis of the increased CBF during seizures.