CHANGES IN BRONCHIAL EPITHELIUM IN RELATION TO CIGARETTE-SMOKING, 1955-1960 VS 1970-1977
CHANGES IN BRONCHIAL EPITHELIUM IN RELATION TO CIGARETTE-SMOKING, 1955-1960 VS 1970-1977
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DOI：
10.1056/nejm197902223000801
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
GARFINKEL, L
中科院分区：
文献类型：
--
作者：
AUERBACH, O;HAMMOND, EC;GARFINKEL, L
为了验证这样一种假设，即香烟烟雾中焦油和尼古丁含量的减少始于20世纪50年代，应该反映在吸烟者支气管上皮的组织学变化上，在尸检时从445名男性（非肺癌死亡）的支气管上取下20,424块切片，以随机顺序进行显微镜检查。在1955-1960年期间，有211人死亡，其中154人经常吸烟；在1970-1977年期间，有234人死亡，其中181人经常吸烟。研究的变化包括基底细胞增生、纤毛缺失和细胞核不典型的细胞。在这两个时期的研究中，这些组织学变化在不吸烟者中发生的频率远低于吸烟者，并且随着吸烟量的增加而增加，并根据年龄进行调整。在1955-1960年间死亡的人群中，0%的人不吸烟，2.6%的人每天吸烟1-19支，13.2%的人每天吸烟20-39支，22.5%的人每天吸烟40支以上。在1970-1977年死亡的人中，这一比例分别为0、0.1、0.8和2.2。
To test the hypothesis that the reduction in tar and nicotine content of cigarette smoke that began in the 1950''s should be reflected by the histologic changes in the bronchial epithelium of cigarette smokers, 20,424 sections taken at autopsy from the bronchial tubes of 445 men (non-lung-cancer deaths) were examined microscopically in random order. There were 211 men who died in 1955-1960, of whom 154 smoked regularly, and 234 men who died in 1970-1977, of whom 181 were regular smokers. Changes studied included basal cell hyperplasia, loss of cilia and occurrence of cells with atypical nuclei. In both periods studied these histologic changes occurred far less frequently in nonsmokers than in cigarette smokers and increased in frequency with amount of smoking, adjusted for age. Sections with advanced histologic changes in those dying in 1955-1960 occurred in 0% of nonsmokers, in 2.6% of those smoking 1-19 cigarettes a day, in 13.2% of those smoking 20-39 and in 22.5% of those smoking 40+ cigarettes a day. In those who died in 1970-1977 the percentages were 0, 0.1, 0.8, and 2.2, respectively.