Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
复制标题
铁死亡相关基因特征预测神经胶质瘤细胞死亡和神经胶质瘤患者进展
DOI：
10.3389/fcell.2020.00538
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发表时间：
2020-07-09
影响因子：
5.5
通讯作者：
Jiang, Tao
中科院分区：
文献类型：
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作者：
Liu, Han-jie;Hu, Hui-min;Jiang, Tao
胶质瘤是一种致命的脑肿瘤，其特点是增殖迅速，治疗耐药。铁下垂是一种新发现的程序性细胞死亡，在肿瘤的发生和发展中起着至关重要的作用。在这项研究中，我们通过分析中国胶质瘤基因组图谱、肿瘤基因组图谱、GSE16011数据集和分子脑肿瘤资料库的全部转录组数据，筛选出铁下垂相关基因的特异性标记，以揭示铁下垂相关基因与胶质瘤的关系。19个与胶质瘤临床和病理特征相关的铁下垂相关基因被鉴定为高度相关。胶质瘤细胞系的功能分析表明，铁性下垂与替莫唑胺耐药、自噬和胶质瘤细胞迁移有关。因此，已确定的铁下垂相关基因与胶质瘤的进展显著相关。
Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression.