The nerve conditioning lesion: A strategy to enhance nerve regeneration
The nerve conditioning lesion: A strategy to enhance nerve regeneration
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神经调节损伤：增强神经再生的策略
DOI：
10.1002/ana.25209
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发表时间：
2018
影响因子：
11.2
通讯作者：
C. Webber
中科院分区：
文献类型：
--
作者：
J. Senger;V. Verge;K. Chan;C. Webber
通过改变细胞的内在代谢，包括再生相关基因（RAG）的上调和轴突生长的结构蛋白的产生，条件性损伤建立了一个高度有利于再生的环境。在这篇综述中，我们评估了40年的研究，提供了一个全面的概述条件性损伤的文献，针对（1）讨论的机制和障碍，神经再生，可以减轻条件性损伤，（2）描述的细胞和分子通路中涉及的条件性损伤的影响，（3）审议如何这些见解可能应用于临床。对再生的相应影响是深远的，与条件神经表现出较长的神经突延伸在体外，增强表达的RAGs内的背根神经节，早期组装和运输的细胞骨架元素，加速轴突生长，并改善功能恢复在体内。虽然这种有前途的技术还不适合在人类中进行，但有潜在的策略，例如可以探索以临床安全和耐受性良好的方式进行神经调节的调节电刺激。神经学年鉴2018;83：691-702
By altering the intrinsic metabolism of the cell, including the upregulation of regeneration‐associated genes (RAGs) and the production of structural proteins for axonal outgrowth, the conditioning lesion sets up an environment highly conducive to regeneration. In this review, we assess 40 years of research to provide a comprehensive overview of the conditioning lesion literature, directed at (1) discussing the mechanisms of and barriers to nerve regeneration that can be mitigated by the conditioning lesion, (2) describing the cellular and molecular pathways implicated in the conditioning lesion effect, and (3) deliberating on how these insights might be applied clinically. The consequential impact on regeneration is profound, with a conditioned nerve demonstrating longer neurite extensions in vitro, enhanced expression of RAGs within the dorsal root ganglia, early assembly and transportation of cytoskeletal elements, accelerated axonal growth, and improved functional recovery in vivo. Although this promising technique is not yet feasible to be performed in humans, there are potential strategies, such as conditioning electrical stimulation that may be explored to allow nerve conditioning in a clinically safe and well‐tolerated manner. Ann Neurol 2018;83:691–702
神经调节损伤后再生蝾螈四肢轴突的缓慢运输增加。
影响因子：
2.7
作者：
Maier,CE;McQuarrie,IG
通讯作者：
McQuarrie,IG