From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes.
From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes.
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从转录组到电生理学：寻找糖尿病的根本原因。
DOI：
10.1016/j.cmet.2020.04.012
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发表时间：
2020
期刊：
影响因子：
29
通讯作者：
Benninger,RichardKP
中科院分区：
文献类型：
--
作者：
Kravets,Vira;Benninger,RichardKP
胰岛内的细胞是异质的。Camunas-Soler等人（2020）实施patch-seq技术以从同一细胞收集转录组学和电生理学数据。通过这样做，他们发现了与功能异质性相关的新基因，并发现这些相关性的变化表明2型糖尿病中的β细胞代偿。
Cells within the islet of Langerhans are heterogeneous. Camunas-Soler et al. (2020) implement a patch-seq technique to collect both transcriptomic and electrophysiological data from the same cell. By doing so, they discover new genes that correlate with functional heterogeneity and find that shifts in these correlations indicate β cell compensation in type 2 diabetes.