A secreted antibacterial neuropeptide shapes the microbiome of Hydra
A secreted antibacterial neuropeptide shapes the microbiome of Hydra
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DOI：
10.1038/s41467-017-00625-1
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发表时间：
2017-09-26
影响因子：
16.6
通讯作者：
Bosch, Thomas C. G.
中科院分区：
文献类型：
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作者：
Augustin, Rene;Schroeder, Katja;Bosch, Thomas C. G.
具有高度特异性的微生物群落的身体上皮表面的定植是所有动物的一个基本特征，然而这些群落被选择和维持的潜在机制还没有被很好地理解。在这里，我们表明，在模式生物海蛇(动物门的一员)外胚层上皮中的感觉神经元和神经节神经元分泌具有抗菌活性的神经肽，这些神经肽可能会塑造身体表面的微生物群。特别是，一种特殊的神经肽，我们称为NDA-1，有助于减少早期发育过程中革兰氏阳性细菌的减少，从而有助于主要定殖物革兰氏阴性曲杆菌沿着体轴的空间分布。我们的发现需要进一步的研究，以测试神经细胞分泌的神经肽是否有助于其他生物体中微生物群落的空间结构。
Colonization of body epithelial surfaces with a highly specific microbial community is a fundamental feature of all animals, yet the underlying mechanisms by which these communities are selected and maintained are not well understood. Here, we show that sensory and ganglion neurons in the ectodermal epithelium of the model organism hydra (a member of the animal phylum Cnidaria) secrete neuropeptides with antibacterial activity that may shape the microbiome on the body surface. In particular, a specific neuropeptide, which we call NDA-1, contributes to the reduction of Gram-positive bacteria during early development and thus to a spatial distribution of the main colonizer, the Gram-negative Curvibacter sp., along the body axis. Our findings warrant further research to test whether neuropeptides secreted by nerve cells contribute to the spatial structure of microbial communities in other organisms.