Commitment of neural crest cells to the sensory neuron lineage.
Commitment of neural crest cells to the sensory neuron lineage.
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神经嵴细胞对感觉神经元谱系的承诺。
DOI：
10.1126/science.2564699
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sieber-Blum,M
中科院分区：
文献类型：
--
作者：
Sieber-Blum,M
克隆培养和针对谱系特异性表位，阶段特异性胚胎抗原-1 （SSEA-1）的单克隆抗体用于分析鹌鹑神经嵴细胞对感觉神经元通路的承诺。在神经节发生时，有两个不同的感觉细胞群。与神经管密切相关的有丝分裂后神经母细胞与形成迁移细胞前沿的大量多能细胞共存，并产生感觉和自主神经母细胞以及黑素细胞。这些数据表明脊髓感觉神经母细胞具有双重起源，并且自主神经和感觉神经谱系的分化主要发生在较晚。
Clonal cultures and monoclonal antibodies against a lineage-specific epitope, stage-specific embryonic antigen-1 (SSEA-1) were used to analyze the commitment of quail neural crest cells to the sensory neuron pathway. There were two distinct populations of sensory cells at the time of gangliogenesis. Postmitotic neuroblasts that remained in close association with the neural tube coexisted with a large number of pluripotent cells that formed the leading edge of the emigrating cells and gave rise to sensory and autonomic neuroblasts and to melanocytes. The data suggest a dual origin of spinal sensory neuroblasts and a predominantly late divergence of the autonomic and sensory lineages.