Endogenous opioids and electrolyte excretion after contralateral renal exclusion.
Endogenous opioids and electrolyte excretion after contralateral renal exclusion.
复制标题
对侧肾排斥后内源性阿片类药物和电解质排泄。
DOI：
10.1152/ajprenal.1983.244.4.f392
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Humphreys,MH
中科院分区：
文献类型：
--
作者：
Ribstein,J;Humphreys,MH
功能性肾块的急性减少导致对侧肾（CK）钠（U Na V）和钾（U K V）排泄增加。我们研究了内源性阿片类药物在这种反应中的作用。在对照实验中，急性单侧肾切除术（AUN）使CK的U Na V从1,788 +/- 1,125 （SD）增加到3,939 +/- 1,819，U K V从1,385 +/- 561增加到2,254 +/- 832 neq/min (P均小于0.005)；在急性单侧输尿管阻塞（UUO）大鼠中也出现了类似的结果。这些增加发生在GFR或平均动脉压没有总体变化的情况下。连续输注阿片受体拮抗剂纳洛酮（0.3 mg）的大鼠。公斤。h-1) AUN和UUO均未引起CK对U Na V或U K V的显著改变；纳洛酮输注本身不改变GFR或基础阳离子排泄率。另一组大鼠通过皮下植入含有75mg吗啡基的微球使其对吗啡耐受。在这些大鼠中，AUN也没有引起CK对U Na V或U K V的任何增加。结果表明，由AUN或UUO引起的肾功能质量的急性减少通过涉及阿片受体的反射途径刺激剩余肾脏的阳离子排泄。
Acute reductions in functioning renal mass result in increases in both sodium (U Na V) and potassium (U K V) excretion by the contralateral kidney (CK). We studied the role of endogenous opioids in this response. In control experiments acute unilateral nephrectomy (AUN) increased U Na V from 1,788 +/- 1,125 (SD) to 3,939 +/- 1,819 and U K V from 1,385 +/- 561 to 2,254 +/- 832 neq/min by the CK (P less than 0.005 for both); similar results occurred in rats undergoing acute unilateral ureteral occlusion (UUO). These increases occurred without overall change in GFR or mean arterial pressure. In rats receiving a continuous infusion of the opiate-receptor antagonist naloxone (0.3 mg . kg-1 . h-1) neither AUN nor UUO produced significant alterations in U Na V or U K V by the CK; naloxone infusion by itself did not alter GFR or basal rates of cation excretion. A separate group of rats was made tolerant to morphine by subcutaneous implantation of pellets containing 75 mg morphine base. In these rats, AUN also failed to produce any increase in U Na V or U K V by the CK. The results suggest that acute reductions in functioning renal mass produced by either AUN or UUO stimulate cation excretion by the remaining kidney through reflex pathways that involve opiate receptors.