The clinical course of alcoholism in 243 mission Indians
The clinical course of alcoholism in 243 mission Indians
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DOI：
10.1176/appi.ajp.161.7.1204
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发表时间：
2004-07-01
影响因子：
17.7
通讯作者：
Gilder, DA
中科院分区：
文献类型：
--
作者：
Ehlers, CL;Wall, TL;Gilder, DA
目的：本研究旨在描述终生诊断为酒精依赖的使命印度男性和女性的出现顺序和酒精相关生活事件的进展。方法：共有407名参与者完成了一次结构化访谈，收集了有关酒精诊断、缓解、戒酒和治疗以及酒精相关生活事件的信息。总共有70%的男性和50%的女性符合酒精依赖的终身诊断标准。酒精依赖的发病年龄更年轻（20岁），病程进展更快（6年），比其他大型酗酒者研究中描述的要快。在酒精相关生活事件的类型和进展的高度相似性之间发现使命印度男性和女性和酗酒者的酗酒遗传学合作研究（COGA）。然而，这项研究中的使命印度人比COGA中的酗酒者更有可能经历酗酒，身体战斗，醉酒驾驶以及与酒精相关的健康问题，并且不太可能认为自己是过度饮酒者，在他们不打算的地方和时间饮酒，并且对他们的饮酒感到内疚。酒精依赖的诊断（61%）和缓解酒精依赖症状（77%）后的precision率也很高，在使命indians.Conclusions：了解过程中的使命印度酗酒可以帮助识别独特的酒精相关的表型，以及指导发展的治疗和预防方案，在这个服务不足的人群。
Objective: This study was conducted to describe the order of appearance and the progression of alcohol-related life events in Mission Indian men and women with a lifetime diagnosis of alcohol dependence.Method: A total of 407 participants completed a structured interview that gathered information on alcohol diagnoses, remissions, abstinences, and treatments as well as alcohol-related life events.Results: A total of 70% of the men and 50% of the women sampled met lifetime diagnostic criteria for alcohol dependence. The age at onset of alcohol dependence was younger (20 years) and the course proceeded more rapidly (6 years) than what has been described in other large studies of alcoholics. A high degree of similarity in the type and progression of alcohol-related life events was found between Mission Indian men and women and alcoholics from the Collaborative Study on the Genetics of Alcoholism (COGA). However, Mission Indians in this study were significantly more likely than alcoholics in the COGA to experience binge drinking, physical fighting, driving while intoxicated, and alcohol-related health problems and were less likely to consider themselves excessive drinkers, drinking where and when they had not intended to, and to experience guilt concerning their drinking. Rates of abstention after an alcohol dependence diagnosis (61%) and remission from alcohol dependence symptoms (77%) were also high in Mission Indians.Conclusions: Understanding the course of Mission Indian alcoholism can help identify unique alcohol-related phenotypes as well as guide the development of treatment and prevention programs in this underserved population.