Effect of stress on prefrontal cortex function
Effect of stress on prefrontal cortex function
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DOI：
10.1007/bf03033299
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发表时间：
2004-01-01
影响因子：
3.7
通讯作者：
Jackson, M
中科院分区：
文献类型：
--
作者：
Moghaddam, B;Jackson, M
压力是导致大多数精神疾病的病因学、病理生理学和治疗结果的主要表观遗传因素。了解压力促进这些过程的机制对改善治疗结果具有重要意义。考虑到功能失调的前额叶皮层与许多精神疾病（如精神分裂症和情绪障碍）有关，描述压力影响前额叶皮层（PFC）功能的机制对于我们理解压力在影响疾病过程中的作用至关重要。本文将回顾最近的机制信息的影响，在PFC的多巴胺和谷氨酸神经传递的压力。
Stress is the major epigenetic factor that contributes to the etiology, pathophysiology, and treatment outcome of most psychiatric disorders. Understanding the mechanisms by which stress contributes to these processes can have important implications for improving therapeutic outcome. Considering that a dysfunctional prefrontal cortex has been implicated in many psychiatric disorders, such as schizophrenia and mood disorders, delineating mechanisms by which stress affects prefrontal cortex (PFC) function is critical to our understanding of the role of stress in influencing the disease process. This paper will review recent mechanistic information about the effects of stress on dopamine and glutamate neurotransmission in the PFC.