Frequency dependence of vestibuloocular reflex thresholds
Frequency dependence of vestibuloocular reflex thresholds
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DOI：
10.1152/jn.00451.2011
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发表时间：
2012-02-01
影响因子：
2.5
通讯作者：
Merfeld, Daniel M.
中科院分区：
文献类型：
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作者：
Haburcakova, Csilla;Lewis, Richard F.;Merfeld, Daniel M.
[10] Haburcakova C，刘易斯RF，Merfeld DM.前庭眼反射阈值的频率依赖性。J Neurophysiol 107：973-983，2012.首次发表于2011年11月9日; doi：10.1152/jn.00451.2011.-大脑如何在噪音存在的情况下处理信号影响了许多行为神经科学。双稳提供了一种分析噪声的方法。虽然知觉阈值已被广泛研究，前庭眼反射（VOR）阈值很少被研究和VOR阈值动力学从来没有，据我们所知，报道。因此，我们评估VOR阈值作为频率的函数。具体来说，我们测量水平VOR阈值引起的恒河猴偏航旋转，使用标准的信号检测方法，如早期人类前庭感知阈值研究中使用的方法。我们测量的VOR阈值范围在0.21和0.76度/秒之间; VOR阈值在测量的频率范围（0.2-3 Hz）内随频率略有增加。这些结果没有模拟人类感知阈值的频率响应，人类感知阈值已经显示出随着频率降低到0.5 Hz以下而显著增加。这些报告的VOR阈值研究结果可能表明人类和非人类灵长类动物的前庭反应之间存在质的差异，但更可能的解释是一种额外的动态神经机制，它不影响VOR，而是通过方向识别任务中的决策过程影响感知阈值。
Haburcakova C, Lewis RF, Merfeld DM. Frequency dependence of vestibuloocular reflex thresholds. J Neurophysiol 107: 973-983, 2012. First published November 9, 2011; doi:10.1152/jn.00451.2011.-How the brain processes signals in the presence of noise impacts much of behavioral neuroscience. Thresholds provide one way to assay noise. While perceptual thresholds have been widely investigated, vestibuloocular reflex (VOR) thresholds have seldom been studied and VOR threshold dynamics have never, to our knowledge, been reported. Therefore, we assessed VOR thresholds as a function of frequency. Specifically, we measured horizontal VOR thresholds evoked by yaw rotation in rhesus monkeys, using standard signal detection approaches like those used in earlier human vestibular perceptual threshold studies. We measured VOR thresholds ranging between 0.21 and 0.76 degrees/s; the VOR thresholds increased slightly with frequency across the measured frequency range (0.2-3 Hz). These results do not mimic the frequency response of human perceptual thresholds that have been shown to increase substantially as frequency decreases below 0.5 Hz. These reported VOR threshold findings could indicate a qualitative difference between vestibular responses of humans and nonhuman primates, but a more likely explanation is an additional dynamic neural mechanism that does not influence the VOR but, rather, influences perceptual thresholds via a decision-making process included in direction recognition tasks.