Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.
Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.
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DOI：
10.3389/fimmu.2015.00363
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发表时间：
2015
影响因子：
7.3
通讯作者：
Guermonprez P
中科院分区：
文献类型：
--
作者：
Gutiérrez-Martínez E;Planès R;Anselmi G;Reynolds M;Menezes S;Adiko AC;Saveanu L;Guermonprez P
树突状细胞（Dendritic cells，DC）具有拾取组织中携带抗原的死亡细胞并迁移至淋巴结的独特能力，在淋巴结中，它们可以通过MHC I类向CD8+ T细胞交叉呈递细胞相关抗原。有强有力的体内证据表明，小鼠XCR1+ DC亚群在此过程中起关键作用。交叉呈递的细胞内过程仍然存在争议，已经提出了几种途径。事实上，大量的研究已经解决了使用各种来源的抗原和抗原呈递细胞的体外交叉呈递的细胞过程。在这里，我们回顾了支持目前的机制模型的体内和体外证据，并讨论了它们与DC亚群交叉呈递细胞相关抗原的生理相关性。
Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse XCR1+ DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.