Thalamocortical dysrhythmia in patients with schizophrenia spectrum disorder and individuals at clinical high risk for psychosis
Thalamocortical dysrhythmia in patients with schizophrenia spectrum disorder and individuals at clinical high risk for psychosis
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DOI：
10.1038/s41386-021-01180-6
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发表时间：
2021-10-04
影响因子：
7.6
通讯作者：
Kwon, Jun Soo
中科院分区：
文献类型：
--
作者：
Kim, Minah;Lee, Tak Hyung;Kwon, Jun Soo
丘脑皮质节律异常（TCD）是一种以异常静息状态丘脑振荡模式为特征的模型，其中α节律被低频和高频节律的交叉频率耦合所取代。虽然丘脑功能紊乱被认为是精神分裂症的重要病理生理机制，但关于精神分裂症谱系障碍（SSD）患者和精神病临床高危人群的TCD模型的知识有限。共有169名SSD患者、106名精神病患者和105名健康对照（hc）接受静息状态脑电图记录。我们进行了1至49 Hz的平均全球场强（MGFP）频谱分析以及源级θ相位- γ振幅耦合（TGC）分析，并比较了各组间静息状态的振荡模式。研究患者组TGC值改变与精神病症状严重程度的相关性。低、高频MGFP谱在SSD组和CHR组均大于HC组。SSD患者的TGC大于右侧额叶、右侧顶叶、左右边缘叶的hc。在SSD患者中，右侧额叶和边缘叶较大的TGC与阳性症状严重程度相关。然而，在广泛的皮质区域，CHR组的TGC与hc组相当，比SSD组的TGC小。在坦率的精神障碍发作并伴有明显的阳性症状后，TCD模式可能很明显。没有明显精神病症状的精神病危险状态的特征可能是低频率和高频活动异常增加，TGC相对保留。
Thalamocortical dysrhythmia (TCD) is a model characterized by abnormal resting-state thalamic oscillatory patterns where the alpha rhythm is replaced by cross-frequency coupling of low- and high-frequency rhythms. Although disrupted thalamic function is a suggested important pathophysiological mechanism underlying schizophrenia, knowledge regarding the TCD model in schizophrenia spectrum disorder (SSD) patients and individuals at clinical high risk (CHR) for psychosis is limited. A total of 169 SSD patients, 106 individuals at CHR for psychosis, and 105 healthy controls (HCs) underwent resting-state electroencephalography recordings. We performed mean global field power (MGFP) spectral analysis between 1 and 49 Hz as well as source-level theta phase-gamma amplitude coupling (TGC) analysis and compared resting-state oscillatory patterns across groups. Correlations between altered TGC values and psychotic symptom severity in the patient group were investigated. Spectral MGFP of low- and high-frequencies was larger in the SSD and CHR groups than in the HC group. The TGC of SSD patients was greater than that of HCs in the right frontal, right parietal, and left and right limbic lobes. Greater TGC in the right frontal and limbic lobes was associated with positive symptom severity in SSD patients. However, TGC in the CHR group was comparable to that in the HCs and was smaller than that in the SSD group in widespread cortical regions. The TCD pattern may be apparent after frank psychotic disorder onset in tandem with overt positive symptoms. A psychosis-risk state without overt psychotic symptoms could be characterized by abnormally increased low- and high-frequency activities with relatively preserved TGC.