Prognostic value of NT-proBNP in patients with severe COVID-19
Prognostic value of NT-proBNP in patients with severe COVID-19
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DOI：
10.1186/s12931-020-01352-w
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发表时间：
2020-04-15
影响因子：
5.8
通讯作者：
Zhang, Dong-ying
中科院分区：
文献类型：
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作者：
Gao, Lei;Jiang, Dan;Zhang, Dong-ying
背景由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)在中国暴发的2019年冠状病毒病(新冠肺炎)已被宣布为国际关注的突发公共卫生事件。心脏损伤是新冠肺炎住院患者的常见病。然而，N末端前体B型利钠肽(NT-ProBNP)是否能预测重症新冠肺炎患者的预后尚不清楚。方法本研究最初从连续样本中纳入102例重症新冠肺炎患者。在筛选不合格病例后，本研究对54例患者进行了分析。主要结果是住院死亡，定义为病死率。研究信息和随访数据从他们的医疗记录中获得。结果NT-proBNP预测院内死亡的最佳临界值为88.64 pg/mL，敏感性为100%，特异性为66.67%。NT-proBNP值高(88.64 pg/m L)的患者在随访期间的死亡风险显著高于低值(
Background The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown. Methods The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records. Results The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (