Antivirals: Past, Present and Future
Antivirals: Past, Present and Future
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DOI：
10.1007/978-981-13-9073-9_22
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发表时间：
2019-06-06
期刊：
影响因子：
--
通讯作者：
Niaz K
中科院分区：
文献类型：
--
作者：
Bule M;Khan F;Niaz K
在新时代，随着用于有效控制病毒性疾病的疫苗的开发，抗病毒剂的使用沿着增加。抗病毒药物的主要目的是尽量减少对宿主系统的伤害，并根除致命的病毒性疾病。然而，与细菌和真菌相比，病毒在宿主系统中的复制代表了巨大的治疗挑战。抗病毒药物不仅渗透破坏病毒的细胞分裂，而且对宿主的正常生理途径产生负面影响。由于这些问题，抗病毒药剂具有比抗菌药物窄的治疗指数。肾毒性是抗病毒药物在人和动物体内的主要不良反应。在本章中，我们总结了抗病毒药物的过去，现在和未来的前景，主要集中在动物，杂项药物，天然产物，草药和再利用药物的抗病毒药物的简史。
The uses of antiviral agents are increasing in the new era along with the development of vaccines for the effective control of viral diseases. The main aims of antiviral agents are to minimize harm to the host system and eradicate deadly viral diseases. However, the replications of viruses in host system represent a massive therapeutic challenge than bacteria and fungi. Antiviral drugs not just penetrate to disrupt the virus’ cellular divisions but also have a negative impact on normal physiological pathways in the host. Due to these issues, antiviral agents have a narrow therapeutic index than antibacterial drugs. Nephrotoxicity is the main adverse reaction of antiviral drugs in human and animals. In this chapter, we summarize the antiviral agents’ past, present and future perspectives with the main focus on the brief history of antiviral in animals, miscellaneous drugs, natural products, herbal and repurposing drugs.