Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension.
Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension.
复制标题
达尔株遗传性高血压中动脉肌膜特性未改变。
DOI：
10.1152/ajpheart.1981.241.2.h224
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Hermsmeyer,K
中科院分区：
文献类型：
--
作者：
Abel,PW;Trapani,A;Matsuki,N;Ingram,MJ;Ingram,FD;Hermsmeyer,K
为了表征 Dahl 品系高血压大鼠的动脉肌膜特性，我们测量了尾动脉对去甲肾上腺素和血清素的收缩敏感性、16 和 37 摄氏度下的膜电位以及细胞内钾、钠和氯含量。饲喂低盐或高盐饮食的达尔耐盐（R）菌株和饲喂低盐饮食的达尔盐敏感（S）菌株保持正常血压。高盐饮食的 Dahl S 品系在高盐喂养 4 周后出现高血压。高血压组和三个正常血压组之间的去甲肾上腺素或血清素有效浓度 (EC) EC50、EC10 或最大反应没有显着差异。在 37 和 16 摄氏度下测量的膜电位以及细胞内钾、钠和氯浓度的电子探针分析显示四组动物之间没有显着差异。这些结果表明，遗传性高血压达尔盐敏感大鼠的动脉肌膜机制没有改变。
To characterize membrane properties of arterial muscle from Dahl strain hypertensive rats, we measured caudal artery contractile sensitivity to norepinephrine and serotonin, membrane potential at 16 and 37 degrees C, and intracellular potassium, sodium, and chloride content. Dahl salt-resistant (R) strain fed low- or high-salt diets and Dahl salt-sensitive (S) strain fed a low-salt diet remained normotensive. The Dahl S strain on high-salt diets became hypertensive after 4 wk of high salt feeding. There was no significant difference in the norepinephrine or serotonin effective concentration (EC) EC50, EC10, or maximum response between the hypertensive and any of the three normotensive groups. Membrane potential measured at 37 and 16 degrees C and electron-probe analysis of intracellular potassium, sodium, and chloride concentration showed no significant differences between the four groups of animals. These results that arterial muscle membrane mechanisms are not altered in genetically hypertensive Dahl salt-sensitive rats.