A novel technique for increasing charge injection capacity of neural electrodes for efficacious and safe neural stimulation.
A novel technique for increasing charge injection capacity of neural electrodes for efficacious and safe neural stimulation.
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一种提高神经电极电荷注入能力以实现有效且安全的神经刺激的新技术。
DOI：
10.1109/embc.2012.6347151
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Solzbacher,Florian
中科院分区：
文献类型：
--
作者：
Negi,Sandeep;Bhandari,Rajmohan;Solzbacher,Florian
神经假体需要长期植入的小面积穿透电极阵列，可以刺激和记录神经活动。对神经电极的基本要求是具有低的界面阻抗和大的电荷注入容量。为了实现这一基本要求，我们开发了一种新的技术来修改犹他州电极阵列（UEA）的表面，以增加真实的表面积，而不改变几何表面积。将Pt涂覆在改性和未改性（对照）UEA上，并测量和比较电化学表征，如阻抗和CIC。表面修饰电极的阻抗和CIC分别为~188 Ohm和~24 mC/cm 2。与对照样品相比，增加电极的真实的表面积使阻抗降低1000倍，并使CIC增加80倍。改性UEA的CIC显著高于文献中报道的任何材料，高于溅射的氧化铱（4 mC/cm 2）或PEDOT（15 mC/cm 2）。
Neural prostheses require chronically implanted small area penetrating electrode arrays that can stimulate and record neural activity. The fundamental requirement of neural electrodes is to have low interface impedance and large charge injection capacity (CIC). To achieve this fundamental requirement, we developed a novel technique to modify the surface of the Utah Electrode Array (UEA) to increase the real surface area without changing the geometrical surface area. Pt was coated on modified and unmodified (control) UEAs and electrochemical characterization such as impedance and CIC was measured and compared. The surface modified electrode impedance and CIC was ~188 Ohm and ~24 mC/cm2respectively. Increasing the real surface area of electrodes decreases the impedance by 1000 times and increases the CIC by 80 times compared to the control samples. The CIC of modified UEA was significantly higher than of any material reported in the literature, higher than sputtered iridium oxide (4 mC/cm2) or PEDOT (15 mC/cm2).