New aspects in cardiac L-type Ca2+ channel regulation.
New aspects in cardiac L-type Ca2+ channel regulation.
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DOI：
10.1042/bst20190229
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发表时间：
2020-02
影响因子：
3.9
通讯作者：
Tamara Pallien;E. Klussmann
中科院分区：
文献类型：
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作者：
Tamara Pallien;E. Klussmann
心脏兴奋-收缩偶联由Ca 2+离子通过电压门控L-型钙通道跨质膜内流启动。这个过程是由信道开放概率和信道定位的调制紧密调节的。蛋白激酶A（PKA）与该通道密切相关，是其功能的主要调节因子之一。该激酶是否通过关键残基的磷酸化或通过替代机制调节通道开放概率尚不清楚。本文综述了PKA介导的通道调节的最新研究结果，并将强调最近发现的调节机制，是独立的PKA活性，涉及蛋白质-蛋白质相互作用和通道定位。
Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. Protein kinase A (PKA) is found in close association with the channel and is one of the main regulators of its function. Whether this kinase is modulating the channel open probability by phosphorylation of key residues or via alternative mechanisms is unclear. This review summarizes recent findings regarding the PKA-mediated channel modulation and will highlight recently discovered regulatory mechanisms that are independent of PKA activity and involve protein-protein interactions and channel localization.