Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
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DOI：
10.1242/jcs.114827
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发表时间：
2012-12-01
影响因子：
4
通讯作者：
Brunet, Anne
中科院分区：
文献类型：
--
作者：
Rafalski, Victoria A.;Mancini, Elena;Brunet, Anne
代谢受年龄、食物摄入量以及糖尿病和肥胖等疾病的影响。生理或病理代谢变化如何影响对组织稳态至关重要的干细胞？这篇评论回顾了最近的证据，即干细胞具有与分化细胞不同的代谢需求，并且控制干细胞自我更新和分化的分子机制在功能上与细胞的代谢状态和周围干细胞生态位相关。此外，我们提出了如何能量传感信号分子和代谢调节剂涉及在干细胞自我更新和分化的调节。最后，我们讨论了诱导多能干细胞代谢的新兴文献，以及如何操纵代谢途径可能有助于细胞重编程。确定能量代谢如何调节干细胞的命运应该揭示衰老过程中发生的组织再生下降，并促进退行性或代谢性疾病治疗的发展。
Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity. How do physiological or pathological metabolic changes influence stem cells, which are crucial for tissue homeostasis? This Commentary reviews recent evidence that stem cells have different metabolic demands than differentiated cells, and that the molecular mechanisms that control stem cell self-renewal and differentiation are functionally connected to the metabolic state of the cell and the surrounding stem cell niche. Furthermore, we present how energy-sensing signaling molecules and metabolism regulators are implicated in the regulation of stem cell self-renewal and differentiation. Finally, we discuss the emerging literature on the metabolism of induced pluripotent stem cells and how manipulating metabolic pathways might aid cellular reprogramming. Determining how energy metabolism regulates stem cell fate should shed light on the decline in tissue regeneration that occurs during aging and facilitate the development of therapies for degenerative or metabolic diseases.