Morbidity of Tokyo-Area centenarians and its relationship to functional status
Morbidity of Tokyo-Area centenarians and its relationship to functional status
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DOI：
10.1093/gerona/62.7.774
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发表时间：
2007-07-01
影响因子：
5.1
通讯作者：
Kitagawa, Koji
中科院分区：
文献类型：
--
作者：
Takayama, Michiyo;Hirose, Nobuyoshi;Kitagawa, Koji
背景西方国家的研究表明，大多数百岁老人都是患有多种合并症的幸存者。然而，日本百岁老人的发病率及其与功能状态的关系尚未阐明。本研究的目的是阐明百岁老人的身体和认知功能的发病率的关联。我们研究了东京地区的百岁老人，以确定他们的发病率的配置文件，以及如何这种发病率与他们的功能状态。我们研究了居住在东京的302名百岁老人（101.2 +/- 1.8岁; 65名男性，237名女性），并评估了他们的身体状况，发病率和药物使用情况。采用Barthel指数和临床痴呆评分评估患者的日常生活能力和认知功能。超过95%的百岁老人患有慢性病。男性的身体和认知功能都明显更高。目前和以前最常见的疾病包括高血压、心脏病、中风、骨折和白内障。骨折在女性中更常见。糖尿病不常见。有中风或骨折史的百岁老人的身体和认知功能特别差，而那些有高血压的百岁老人往往表现出高水平的身体和认知功能。几乎所有的百岁老人都患有慢性病。中风和骨折与较差的功能相关;因此，我们假设预防中风和骨折可能会改善高龄老人的功能状态。
Background. Research in Western countries has shown most centenarians to be survivors with multiple comorbidities. However, Japanese centenarians' morbidity and its relationship to functional status has yet to be elucidated. The aim of this study is to clarify the association of morbidity with the physical and cognitive function of centenarians. We examined Tokyo-area centenarians to determine their kinds of morbidity profiles and how such morbidity related to their functional status.Methods. We studied 302 centenarians living in Tokyo (101.2 +/- 1.8 years; 65 men, 237 women), and assessed their physical status, morbidity, and use of medication. Activities of daily living and cognitive function were also assessed using the Barthel Index and the Clinical Dementia Rating.Results. More than 95% of the centenarians had chronic diseases. Both the physical and cognitive functions were significantly higher in men. The present and previous illnesses most frequently included hypertension, heart disease, stroke, fractures, and cataracts. Fractures were observed significantly more frequently in women. Diabetes mellitus was uncommon. The physical and cognitive function of centenarians with a history of stroke or fracture were particularly poor, whereas those centenarians with hypertension tended to show a high level of physical and cognitive function.Conclusions. Almost all centenarians had chronic diseases. Stroke and fracture were correlated with poorer function; therefore, we hypothesize that prevention of stroke and fracture might improve functional status in the oldest-old.