2-Hydroxyestradiol enhances binge onset in female rats and reduces prefrontal cortical dopamine in male rats
2-Hydroxyestradiol enhances binge onset in female rats and reduces prefrontal cortical dopamine in male rats
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DOI：
10.1016/j.yhbeh.2012.10.010
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发表时间：
2013-01-01
影响因子：
3.5
通讯作者：
Corwin, R. L. W.
中科院分区：
文献类型：
--
作者：
Babbs, R. K.;Unger, E. L.;Corwin, R. L. W.
Women are more likely to suffer from a bingeing-related eating disorder, which is surprising, since estradiol reduces meal size and is associated with reduced binge frequency. This apparent contradiction may involve the estradiol metabolite, 2-hydroxyestradiol. We previously reported that female rats had faster escalations in shortening intake during the development of bingeing than did males, but acute administration of 2-hydroxyestradiol increased the intake of vegetable shortening to a greater extent in male rats once bingeing was established. Here, we report two separate studies that follow up these previous findings. In the first, we hypothesized that chronic exposure to 2-hydroxyestradiol would promote escalation of bingeing during binge development in ovariectomized female rats. In the second, we hypothesized that acute exposure to 2-hydroxyestradiol would enhance dopamine signaling in the prefrontal cortex after bingeing was established in male rats. In study 1, non-food-deprived female rats were separated into 3 groups: ovariectomized (OVX) with chronic 2-hydroxyestradiol supplementation (E), OVX with vehicle supplementation (0), and intact with vehicle (I). Each group was given access to an optional source of dietary fat (shortening) on Mon, Wed, and Fri for 4 weeks. 2-hydroxyestradiol supplementation prevented OVX-induced weight gain and enhanced escalation of shortening intake over the four-week period (ps
