Functional coupling of human cortical sensorimotor areas during bimanual skill acquisition
Functional coupling of human cortical sensorimotor areas during bimanual skill acquisition
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DOI：
10.1093/brain/122.5.855
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发表时间：
1999-05-01
期刊：
影响因子：
14.5
通讯作者：
Gerloff, C
中科院分区：
文献类型：
--
作者：
Andres, FG;Mima, T;Gerloff, C
双手协调熟练的手指运动是人类运动系统的高级能力，几乎总是需要训练。本研究采用多通道表面脑电的任务相关相干性（TRCoh）和任务相关功率（TRPow）分析方法，探讨了人类双手技能获得过程中感觉运动区域的功能耦合和区域激活。我们关注的是与双手学习相关的半球间耦合的变化。TRCoh和TRPow的估计融合过程中的两个过度学习unimanual手指轻敲序列到一个新的双手序列，之前和之后的30分钟的训练期在18名正常志愿者。控制实验包括学习和重复复杂和简单的单手手指序列。结果表明，在学习的早期，纵裂TRCoh有选择性地增加（P < 0.0001），在单手控制任务中，纵裂TRCoh也有增加，但幅度较低。训练改善了双手序列性能（从58.3 +/- 24.1到83.7 +/-15.3%正确序列）。训练后，半球间（双手）TRCoh再次下降，从而接近单手控制的水平。我们认为，TRCoh的最初增加反映了半球间交流的变化，这些变化与双手学习特别相关，并可能通过胼胝体传递，目前的数据也可能为临床观察提供神经生理学解释，即胼胝体损伤的患者可能在获得新的双手任务时表现出缺陷，但不一定在执行先前学习的双手任务时表现出缺陷。活动
Bimanual co-ordination of skilled finger movements is a high-level capability of the human motor system and virtually always requires training. Little is known about the physiological processes underlying successful bimanual performance and skill acquisition, In the present study, we used task-related coherence (TRCoh) and task-related power (TRPow) analysis of multichannel surface EEG to investigate the functional coupling and regional activation of human sensorimotor regions during bimanual skill acquisition. We focused on changes in interhemispheric coupling associated with bimanual learning. TRCoh and TRPow were estimated during the fusion of two overlearned unimanual finger-tapping sequences into one novel bimanual sequence, before and after a 30-min training period in 18 normal volunteers. Control experiments included learning and repetition of complex and simple unimanual finger sequences. The main finding was a significant increase in interhemispheric TRCoh selectively in the early learning stage (P < 0.0001), Interhemispheric TRCoh was also present during the unimanual control tasks, but with lower magnitude, even if learning was involved. Training improved bimanual sequence performance (from 58.3 +/- 24.1 to 83.7 +/- 15.3 % correct sequences). After training, interhemispheric (bimanual) TRCoh decreased again, thereby approaching levels similar to those in the unimanual controls. We propose that the initial increase in TRCoh reflects changes in interhemispheric communication that are specifically related to bimanual learning and may be relayed through the corpus callosum, The present data might also offer a neurophysiological explanation for the clinical observation that patients with lesions of the corpus callosum may show deficits in the acquisition of novel bimanual tasks but not necessarily in the execution of previously learned bimanual activities.