Erratum: Regio- and Stereoselective Rhodium(II)-Catalyzed C-H Functionalization of Cyclobutanes.
Erratum: Regio- and Stereoselective Rhodium(II)-Catalyzed C-H Functionalization of Cyclobutanes.
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勘误表：环丁烷的区域选择性和立体选择性铑 (II) 催化的 C-H 官能化。
DOI：
10.1016/j.chempr.2020.01.007
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发表时间：
2020
期刊：
影响因子：
23.5
通讯作者：
Davies,HuwML
中科院分区：
文献类型：
--
作者：
Garlets,ZacharyJ;Wertz,BenjaminD;Liu,Wenbin;Voight,EricA;Davies,HuwML
Recent developments in controlled C–H functionalization transformations continue to inspire new retrosynthetic disconnections. One tactic in C–H functionalization is the intermolecular C–H insertion reaction of rhodium-bound carbenes. These intermediates can undergo highly selective transformations through the modulation of the ligand framework of the rhodium catalyst. This work describes our continued efforts toward differentiating C–H bonds in the same molecule by judicious catalyst choice. Substituted cyclobutanes that exist as a mixture of interconverting conformers and possess neighboring C–H bonds within a highly strained framework are the targets herein for challenging the current suite of catalysts. Although most C–H functionalization tactics focus on generating 1,2-disubstituted cyclobutanes via substrate-controlled directing-group methods, the regiodivergent methods discussed in this paper provide access to chiral 1,1-disubstituted andcis-1,3-disubstituted cyclobutanes simply by changing the catalyst identity, thus permitting entry to novel chemical space.
