PLASMODIUM-GALLINACEUM - TRANSMISSION-BLOCKING IMMUNITY IN CHICKENS .1. COMPARATIVE IMMUNOGENICITY OF GAMETOCYTE-CONTAINING AND GAMETE-CONTAINING PREPARATIONS
PLASMODIUM-GALLINACEUM - TRANSMISSION-BLOCKING IMMUNITY IN CHICKENS .1. COMPARATIVE IMMUNOGENICITY OF GAMETOCYTE-CONTAINING AND GAMETE-CONTAINING PREPARATIONS
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DOI：
10.1016/0014-4894(79)90072-9
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发表时间：
1979-01-01
影响因子：
2.1
通讯作者：
MCAULIFFE, FM
中科院分区：
文献类型：
--
作者：
CARTER, R;GWADZ, RW;MCAULIFFE, FM
Immunization of chickens by i.v. inoculation of preparations derived from blood infected with P. gallinaceum led to reduced infectivity to mosquitoes (Aedes aegypti) during subsequently induced blood infection but had little effect on the course of asexual parasitemia. Immunization with preparations containing intracellular gametocytes was much less effective than immunization with preparations in which the extracellular gametes were released during gametogenesis (emergence and exflagellation) prior to inoculation. By far, the most effective material were preparations of partially purified gametes of both sexes. Three weekly inoculations of this material resulted in 99.99% suppression of infectivity to mosquitoes during subsequently induced blood infection. Preparations of purified gamete material from which gametes of 1 or another sex were absent were considerably less effective as transmission-blocking immunogens than the mixed gamete preparation. The 2 sexes of gamete may act synergistically to induce transmission-blocking immunity.
