Imaging of Primary Brain Tumors and Metastases with Fast Quantitative 3-Dimensional Magnetization Transfer
Imaging of Primary Brain Tumors and Metastases with Fast Quantitative 3-Dimensional Magnetization Transfer
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DOI：
10.1111/jon.12222
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发表时间：
2015-11-01
影响因子：
2.4
通讯作者：
Stippich, Christoph
中科院分区：
文献类型：
--
作者：
Garcia, Meritxell;Gloor, Monika;Stippich, Christoph
背景和结论本研究评估了磁化传递（MT）成像是否为脑肿瘤的常规MRI提供了额外的信息。对于本研究中研究的3个最大的肿瘤组，多形性胶质母细胞瘤（GBM）、脑膜瘤和脑膜瘤进行了统计学比较。分析的MT参数包括磁化传递率（MTR）和4个定量MT参数（qMT）：弛豫时间（T1，T2）、交换速率（kf）和大分子含量（F）。平衡稳态自由进动的高分辨率全脑MTR和qMT成像的总成像时间需要9分钟。选择了五个ROI：对比增强（T1 W-CE）、非对比增强（T1 W-non-CE）、近端高信号（T2 W-pSI）、远端高信号（T2 W-dSI）和参考（ref）。与参考相比，MTS病理显示显著（P <0.05）MT变化（MTR和qMT）。GBM、脑膜瘤和转移瘤的T1 W-CE、T1 W-non-CE和T2 W-pSI ROI显示MTR和qMT估计值存在显著差异。在不同病变的几个ROI中观察到类似的MTR，但qMT值显著不同。MT地图（MTR和qMT）表明，在大多数神经胶质tumors.CONCLUSIONSMTR和qMT成像的组织出现不受影响的变化，使脑肿瘤之间的更好的区分，并提供额外的信息，MRI。
BACKGROUND AND PURPOSEThis study assesses whether magnetization transfer (MT) imaging provides additive information to conventional MRI in brain tumors.METHODSMT data of 26 patients with neoplastic and metastatic brain tumors were analyzed at 1.5 T. For the 3 largest tumor groups investigated in this studyglioblastoma multiforme (GBM), meningiomas, and metastasesstatistical comparisons were performed. Analyzed MT parameters included the magnetization transfer ratio (MTR) and 4 quantitative MT parameters (qMT): Relaxation times (T1, T2), exchange rate (kf), and macromolecular content (F). Total imaging time of high-resolution whole brain MTR and qMT imaging with balanced steady-state free precession required 9 minutes. Five ROIs were chosen: Contrast-enhancing (T1W-CE), noncontrast-enhancing (T1W-non-CE), proximal hyperintensity (T2W-pSI), distal hyperintensity (T2W-dSI), and a reference (ref).RESULTSPathologies showed significant (P < .05) MT changes (MTR and qMT) compared to the reference. The T1W-CE, T1W-non-CE, and T2W-pSI ROIs of GBMs, meningiomas, and metastases showed significant differences in MTR and qMT estimates. Similar MTR with significant different qMT values were observed in several ROIs among different lesions. MT maps (MTR and qMT) indicated changes in tissue appearing unaffected on MRI in most glial tumors.CONCLUSIONSMTR and qMT imaging enables a better differentiation between brain tumors and provides additive information to MRI.