Is there evidence for neuronal loss in schizophrenia?
Is there evidence for neuronal loss in schizophrenia?
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DOI：
10.1080/09540269775295
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发表时间：
1997-12-01
影响因子：
2.8
通讯作者：
Benes, FM
中科院分区：
文献类型：
--
作者：
Benes, FM
在1972年至1991年期间发表的几乎所有精神分裂症细胞计数研究都报告了几个不同皮质边缘区域神经元密度的减少。然而，最近有几个研究小组未能在精神分裂症患者的皮层中发现这种类型的变化。这些不一致的结果进行了讨论有关的各种因素，包括患者样本的异质性，各种方式，组织已被处理，使用二维与三维细胞计数技术和不同的大脑区域进行了检查tit各种研究。虽然没有一个单一的因素可以解释的差异，它已经变得很清楚，神经lass在精神分裂症，如果存在的话，是相当微妙的，可能是既不必要也不足以解释这种疾病的发生。
Almost all cell counting studies of schizophrenia published between 1972 and 1991 have reported a reduction in the density of neurons in several different corticolimbic regions. More recently, however, several groups have failed to detect a change of this type in the cortex of schizophrenic patients. These discrepant findings are discussed in relation to a variety of factors, including the heterogeneity of patient samples, various ways that tissues have been processed, the use of two-dimensional versus three-dimensional cell counting techniques and differences in the brain regions that were examined tit various studies. Although no single factor can explain the discrepancies, it has become clear that neuronal lass in schizophrenia, where present, is quite subtle and is probably neither necessary nor sufficient to explain the occurrence of this disorder.