HYPERPIGMENTATION OF THE SKIN ASSOCIATED WITH MINOCYCLINE THERAPY
HYPERPIGMENTATION OF THE SKIN ASSOCIATED WITH MINOCYCLINE THERAPY
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DOI：
10.1001/archderm.121.5.618
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
IATROPOULOS, MJ
中科院分区：
文献类型：
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作者：
GORDON, G;SPARANO, BM;IATROPOULOS, MJ
采用光镜、电镜、组织化学和能量色散x射线分析对二甲胺四环素治疗患者的皮肤活检标本和变色指甲进行检查。色素沉着和邻近正常色素沉着的皮肤样本在真皮层中都含有富含色素的巨噬细胞，尽管这些细胞在色素沉着的皮肤样本中数量更多。元素分析表明，色素沉着的皮肤样本的色素沉积物和角质层都含有铁和钙。二甲胺四环素治疗患者的指甲变色区域也含有铁和钙。皮肤和指甲变色可能是由于二甲胺四环素的铁螯合物和/或二甲胺四环素的醌类衍生物的存在。正常和色素沉着的皮肤中含铁色素的存在可能使这些患者易形成二甲胺环素相关色素。
Skin biopsy specimens and discolored fingernails from minocycline-treated patients were examined by light and electron microscopy, histochemistry and energy-dispersive X-ray analysis. Both hyperpigmented and adjacent normally pigmented skin samples contained pigment-laden macrophages in the dermis, although these cells were more numerous in the hyperpigmented skin samples. Elemental analysis showed that both pigment deposits and stratum corneum of hyperpigmented skin samples contained Fe and Ca. Discolored areas of fingernails from a minocycline-treated patient also contained Fe and Ca. Both skin and nail discoloration were possibly due to the presence of an iron chelate of minocycline and/or quinoid derivatives of minocycline. The presence of iron-containing pigment in normal as well as hyperpigmented skin may have predisposed to formation of minocycline-associated pigment in these patients.