Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours
Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours
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DOI：
10.1007/s00259-007-0450-1
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发表时间：
2007-10-01
影响因子：
9.1
通讯作者：
Haberkorn, U.
中科院分区：
文献类型：
--
作者：
Buchmann, I.;Henze, M.;Haberkorn, U.
目的神经内分泌肿瘤(Net)可以用放射性标记的生长抑素类似物进行核素显像。本研究的目的是比较Ga-68-DOTATOC PET和In-111-DTPAOC SPECT(Octreoscan)在网络表现检测中的价值。使用标准技术进行Ga-68-DOTATOC PET和In-111-DTPAOC SPECT。在两次治疗之间没有进行治疗。根据PET检查结果计算平均和最大标准摄取值(SUV)。根据SPECT结果计算肿瘤/非肿瘤的比率。结果Ga-68-DOTATOC PET阳性病灶的SUV范围为0.7~29.3(平均SUV)和0.9~34.4(最大SUV)。In-111-DTPAOC SPECT肿瘤/非肿瘤比值为1.8~7.3。Ga-68-DOTATOC正电子发射计算机体层摄影对肺部和骨骼的显影效率高于In-111-DTPAOC SPECT。所有不一致的肺部表现和77.8%的不一致骨性表现被证实为真正阳性的PET解释。在肝脏和脑的区域比较中，Ga-68-DOTATOC PET和In-111-DTPAOC SPECT是相同的。在区域分析中，在淋巴结、胰腺和胃肠道系统，这两种技术的不同价值并未显示出来。结论Ga-68-DOTATOC PET对肺、骨骼净表现的检出优于In-111-DTPAOC SPECT，对肝、脑净表现的检出优于In-111-DTPAOC SPECT。GA-68-DOTATOC PET在指导临床治疗方面具有一定的优势。
Purpose Neuroendocrine tumours (NETs) can be imaged with scintigraphy using radiolabelled somatostatin analogues. The aim of our study was to compare the value of Ga-68-DOTATOC PET and In-111-DTPAOC SPECT (Octreoscan) in the detection of NET manifestations.Methods Twenty-seven NET patients were prospectively examined. Ga-68-DOTATOC PET and In-111-DTPAOC SPECT were performed using standard techniques. Treatment was not applied in between. Mean and maximum standardised uptake values (SUVs) were calculated for PET findings. Tumour/non-tumour ratios were calculated for SPECT findings. Findings were compared by a region-by-region analysis and verified with histopathology, CT and MRI within 21 days.Results SUVs of positive lesions on Ga-68-DOTATOC PET ranged from 0.7 to 29.3 (mean SUV) and from 0.9 to 34.4 (maximum SUV). Tumour/non-tumour ratios on In-111-DTPAOC SPECT ranged from 1.8 to 7.3. In imaging lung and skeletal manifestations, Ga-68-DOTATOC PET was more efficient than In-111-DTPAOC SPECT. All discrepant lung findings and 77.8% of discrepant osseous findings were verified as true positive PET interpretations. In regional comparison of liver and brain, Ga-68-DOTATOC PET and In-111-DTPAOC SPECT were identical. In lymph nodes, the pancreas and the gastro-intestinal system, different values of the two techniques were not indicated in regional analyses. In a single patient, surgical interventions were changed on the basis of Ga-68-DOTATOC PET findings.Conclusion Ga-68-DOTATOC PET is superior to In-111-DTPAOC SPECT in the detection of NET manifestations in the lung and skeleton and similar for the detection of NET manifestations in the liver and brain. Ga-68-DOTATOC PET is advantageous in guiding the clinical management.