Medicinal flowers.: XVI.: New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng
Medicinal flowers.: XVI.: New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng
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DOI：
10.1248/cpb.55.1034
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发表时间：
2007-07-01
影响因子：
1.7
通讯作者：
Matsuda, Hisashi
中科院分区：
文献类型：
--
作者：
Yoshikawa, Masayuki;Sugimoto, Sachiko;Matsuda, Hisashi
人参花蕾中的低聚苷组分。A. MEYER（五加科）对乙醇诱导的大鼠胃粘膜损伤具有保护作用。从低聚糖苷馏分中分离出新的达玛烷型三萜四糖苷，floralalcohosides M，N，O和P，以及主要的低聚糖苷Rd和Re。根据化学和物理化学证据，鉴定了新的花旗松苷的结构。人参皂甙Rd（原人参二醇3，20-O-双桥糖甙）对乙醇和消炎痛引起的大鼠胃粘膜损伤有抑制作用。
The oligoglycoside fraction from the flower buds of Panax ginseng C. A. MEYER (Araliaceae) was found to show protective effects on ethanol-induced gastric mucosal lesions in rats. From the oligoglycoside fraction, new dammarane-type triterpene tetraglycosides, floralginsenosides M, N, O, and P, were isolated together with the major oligoglycosides ginsenoside Rd and Re. The structures of the new floralginsenosides were elucidated on the basis of chemical and physicochemical evidence. Ginsenoside Rd (protopanaxadiol 3,20-O-bisdesmoside) exhibited inhibitory effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats.