MicroRNAs in Liver Health and Disease.
MicroRNAs in Liver Health and Disease.
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DOI：
10.1007/s40139-012-0005-4
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发表时间：
2013-03
影响因子：
--
通讯作者：
Ghoshal K
中科院分区：
文献类型：
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作者：
Hsu SH;Ghoshal K
MicroRNAs （miRNAs）是一类短链非编码rna，近十年来在细胞分化、增殖和死亡等生物过程的各个方面得到了广泛而深入的研究。这些发现指出了miRNA在动物基因表达转录后调控中的关键作用，并确立了miRNA作为包括肝脏疾病在内的不同病理生理过程的治疗靶点。在这里，我们讨论了在不同肝脏疾病（如肥胖、肝炎、酒精性和非酒精性脂肪性肝炎、肝硬化和肝细胞癌）以及病理生理状况（如发育异常）中识别失调的mirna的最新进展。我们特别回顾了mirna在这些疾病中的作用，并讨论了这些mirna作为生物标志物和/或临床肝脏病理生物学治疗靶点的潜在影响。最后，我们强调了正在开发的最新技术或临床前和/或临床试验，以补充或抑制不受调节的mirna。
MicroRNAs (miRNAs), a class of short non-coding RNAs, have been studied intensely and extensively in the past decade in every aspect of biological processes, including cell differentiation, proliferation and death. These findings pointed out the pivotal role of miRNA in posttranscriptional control of gene expression in animals and established miRNAs as therapeutic targets for different pathophysiological processes, including liver disease. Here we have discussed the recent advances made in identifying the miRNAs deregulated in different liver diseases such as obesity, hepatitis, alcoholic and nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma, as well as pathophysiological conditions such as developmental abnormality. We have specifically reviewed the role of miRNAs in these diseases and discussed critically potential impacts of these miRNAs as biomarkers and/or therapeutic targets in liver pathobiology in the clinical setting. Finally, we have highlighted the latest techniques or preclinical and/or clinical trials that are being developed to replenish or inhibit the deregulated miRNAs.