Expression of tbx20 RNA during chick heart development
Expression of tbx20 RNA during chick heart development
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DOI：
10.1002/dvdy.20076
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发表时间：
2004-07
影响因子：
2.5
通讯作者：
T. Yamagishi;Y. Nakajima;S. Nishimatsu;T. Nohno;Katsumi Ando;Hiroaki Nakamura
中科院分区：
文献类型：
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作者：
T. Yamagishi;Y. Nakajima;S. Nishimatsu;T. Nohno;Katsumi Ando;Hiroaki Nakamura
T-box基因家族编码一组参与各种发育过程的转录因子。我们从鸡胚中分离了tbx 20基因，并详细研究了其在心脏发育过程中的表达模式。原位杂交结果显示，tbx 20在侧板中胚层表达，随后在原始心管中表达。在环状心脏阶段，tbx 20定位于流出道（OT）和房室（AV）管，其中形成瓣膜间隔内膜垫。在后期阶段，虽然tbx 20主要在新生右心室中表达，但tbx 20的转录物在左心室中下调。这些结果表明，tbx 20可能在心脏发生的各种发育过程中发挥重要作用，如室特化和分隔。发展动力学230：576-580，2004年。© 2004 Wiley利斯公司
The T‐box gene family encodes a set of transcription factors that are involved in various developmental processes. We isolated tbx20 gene from chick embryos and examined in detail its expression patterns during heart development. In situ hybridization showed that tbx20 was expressed in the lateral plate mesoderm and subsequently in the primitive heart tube. At stages of looped heart, tbx20 was localized in the outflow tract (OT) and atrioventricular (AV) canal, in which valvuloseptal endocardial cushion develops. At later stages, although tbx20 was expressed predominantly in the nascent right ventricle, transcripts of tbx20 were down‐regulated in the left ventricle. These results suggest that tbx20 may play important roles in a variety of developmental processes in cardiogenesis, such as chamber‐specification and septation. Developmental Dynamics 230:576–580, 2004. © 2004 Wiley‐Liss, Inc.