A unique role for the human amygdala in novelty detection
A unique role for the human amygdala in novelty detection
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DOI：
10.1016/j.neuroimage.2009.12.083
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发表时间：
2010-04-15
期刊：
影响因子：
5.7
通讯作者：
Zald, David H.
中科院分区：
文献类型：
--
作者：
Blackford, Jennifer Urbano;Buckholtz, Joshua W.;Zald, David H.
先前的研究表明，杏仁核和海马体对新奇事物很敏感;然而，可以区分两种类型的新奇事物-普通的刺激，但在当前环境中是新奇的，以及不寻常的刺激。使用功能磁共振成像，我们研究了血氧依赖水平（BOLD）的人类杏仁核和海马体的反应，新的，常见的对象与新的不寻常的对象。当呈现新的常见刺激时，杏仁核和海马体中的BOLD信号显著增加。然而，对于新的不寻常的刺激，只有杏仁核表现出增加的反应相比，新的共同刺激。这些发现表明，杏仁核对新奇的不寻常的刺激有明显的反应，对新奇感检测电路做出了独特的贡献。(C)2009 Elsevier Inc. All rights reserved.
Previous research indicates that the amygdala and hippocampus are sensitive to novelty; however, two types of novelty can be distinguished - stimuli that are ordinary, but novel in the current context, and stimuli that are unusual. Using functional magnetic resonance imaging, we examined blood oxygen dependent level (BOLD) response of the human amygdala and hippocampus to novel, commonly seen objects versus novel unusual objects. When presented with the novel common stimuli, the BOLD signal increased significantly in both the amygdala and hippocampus. However, for the novel unusual stimuli, only the amygdala showed an increased response compared to the novel common stimuli. These findings suggest that the amygdala is distinctly responsive to novel unusual stimuli, making a unique contribution to the novelty detection circuit. (C) 2009 Elsevier Inc. All rights reserved.